Synthetic analogues of netropsin and distamycin-synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics

• Autorzy: Bartulewicz D. , Bielawski K. , Markowska A. , Zwierz K. , Puckowska A. , Rozanski A.
• Języki publikacji: EN

Abstrakty

EN

A new series of pyridine-containing analogues III-XXII of distamycin A and netropsin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on molecular studies, and two carbocyclic analogues of distamycin A with an N-terminal chloro- or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. The potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.

Słowa kluczowe

EN

molecular modelling; drug design; antitumour drug; antibiotic; netropsin; distamycin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 1
• Opis fizyczny: p.41-57,fig.

Twórcy

autor

Bartulewicz D.

• Medical Academy, A.Mickiewicza 2, 15-230 Bialystok, Poland

autor

Bielawski K.

autor

Markowska A.

autor

Zwierz K.

autor

Puckowska A.

autor

Rozanski A.

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