GA733 genes expression in human gastrointestinal tumours

• Autorzy: Kitlinska J , Wojcierowski J. , Dabrowski A. , Paluszkiewicz P.
• Języki publikacji: EN

Abstrakty

EN

Expression of GA733-1 and GA733-2 genes in gastrointestinal tumours was investigated. Twelve cases of colorectal and stomach cancers were analysed. The Northern blot and RT-PCR methods were used. The second method appeared to be much more sensitive and useful in these investigations. No expression of GA733-1 gene was found in the investigated cases. GA733-2 expression was observed in 83% of colon cancers (five to six analysed cases) and in 33% of stomach cancers (two to six analysed cases). No correlation was found between the expression and clinical properties of tumours. Moreover, in two cases the presence of GA733-2 mRNA was observed in the surrounding morphologically normal tissue. These results indicate that GA733-2 gene can be a good marker of colon but not stomach cancers.

Słowa kluczowe

EN

glycoprotein; stomach adenocarcinoma; human genetics; gene expression; tumour; colon adenocarcinoma; neoantigen; membrane protein; immunotherapy

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 1995
• Tom: 36
• Numer: 3
• Opis fizyczny: p.279-284,fig.

Twórcy

autor

Kitlinska J

• Medical Academy, Radziwillowska 11, 20-950 Lublin, Poland

autor

Wojcierowski J.

autor

Dabrowski A.

autor

Paluszkiewicz P.

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