Benzimidazoles influence on uncoupling of host muscle mitochondria in Trichinella spiralis and T.pseudospiralis infections

• Autorzy: Boczon K , Wandurska-Nowak E , Karczewska M
• Języki publikacji: EN

Abstrakty

EN

In muscle mitochondria of mice infected by Trichinella spiralis larvae and treated by following benzimidazoles: mebendazole (MBZ), oxfendazole (OXF) and thiabendazole (TBZ) their differential influence on uncoupling of host mitochondria was observed. Both MBZ and OXF (in doses of 80 mg/kg of body weight and 60 mg/kg of body weight, respectively) improved the bioenergetic properties of host muscles mitochondria i.e. increase the respiratory control index (RCI) in the muscular phase of this infection. The experiments with the use of OXF in Trichinella pseudospiralis infection have proved that this drug normalizes also in this infection the activity of two mitochondrial inner membrane-located enzymes: mtATPase and SDH in the muscular phase of the infection. A similar effectiveness of OXF in the latter infection was reached using a single and a double dose of the drug (200 mg/kg of body weight, divided into two parts).

Słowa kluczowe

EN

Trichinella pseudospiralis; mitochondrion; host muscle; uncoupling; benzimidazole; Trichinella spiralis

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1993
• Tom: 38
• Numer: 3
• Opis fizyczny: p.136-141,fig.

Twórcy

autor

Boczon K

• Department of Biology and Medical Parasitology, K.Marcinkowski Medical Academy, ul.Fredry 10, 61-701 Poznan, Poland

autor

Wandurska-Nowak E

• Department of Biology and Medical Parasitology, K.Marcinkowski Medical Academy, ul.Fredry 10, 61-701 Poznan, Poland

autor

Karczewska M

• Department of Biology and Medical Parasitology, K.Marcinkowski Medical Academy, ul.Fredry 10, 61-701 Poznan, Poland

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