The UL97 protein kinase of human cytomegalovirus [HCMV] and homologues in other herpesviruses: relevance for virus and host

• Autorzy: Michel D , Mertens T.
• Języki publikacji: EN

Słowa kluczowe

EN

infection; virus; cytomegalovirus; herpesvirus; immunosuppression; host; protein kinase

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.535-536

Twórcy

autor

Michel D

• Universitat Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany

autor

Mertens T.

Bibliografia

• 1. Biron, K.K., Fyfe, J.A., Stanat, S.C., Leslie, L.K., Sorrell, J.B., Lambe, C.U. and Coen, D.M. A human cytomegalovirus mutant resistant to the nucleoside analog 9-[(2-hydroxy-1-(hydroxymethyl) et hoxy] methyll-guanine (BW B759U) induces reduced levels of BW B759U triphosphate. Proc. Natl. Acad. Sci. USA 83 (1986) 8769-8773.
• 2. Sullivan, V., Talarico, C.L., Stanat, S.C., Davis, M., Coen, D.M. and Biron, K.K. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirs-infected cells. Nature 358 (1992) 162-164.
• 3. Littler, E., Stuart, A.D. and Chee, M.S. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 358 (1992) 160-162.
• 4. Zimmermann, A., Wilts, H., Lenhardt, M., Hahn, M. and Mertens, T. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48 (2000) 49-60.
• 5. Prichard, M.N., Gao, N., Jairath, S., Mulambia, G., Krosky, P., Coen, D.M., Parker, B.O. and Pari, G.S. A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency. J. Virol. 73 (1999) 5663-5670.
• 6. He, Z., He, Y., Kim, Y., Chu, L., Ohmstede, C., Biron, K.K. and Coen, D.M. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J. Virol. 71 (1997) 405-411.
• 7. Michel, D., Kramer, S., Höhn, S., Schaarschmidt, P., Wunderlich, K. and Mertens, Th. Amino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation. J. Virol. 73 (1999) 8898-8901.
• 8. Ng, T.I., Talarico, C., Burnette, T.C., Biron, K. and Roizman, B. Partial substitution of the functions of the herpes simplex virus 1 UL13 gene by the human cytomegalovirus UL97 gene. Virology 225 (1996) 347-358.
• 9. Ansari, A. and Emery, V.C. The U69 Gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses. J. Virol. 73 (1999) 3284-3291.
• 10. Marschall, M., Freitag, M., Suchy, P., Romaker, D., Kupfer, R., Hanke, M. and Stamminger, T. The protein kinase pUL97 of human cytomegalovirus interacts with and phosphorylates the DNA polymerase processivity factor pUL44. J. Gen. Virol. (2003) in press.