Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis

• Autorzy: Kania K , Dragojew S. , Jozwiak Z.
• Języki publikacji: EN

Abstrakty

EN

We show that treating human trisomie fibroblasts with anthracyclines - aclarubicin, daunorubicin and idarubicin - leads to certain changes in these cells; namely the activation of caspase 3, morphological changes and an increase in the level of intracellular calcium. These results suggest that anthracycline drugs are also able to induce apoptosis in pathological, trisomic cells.

Słowa kluczowe

EN

drug treatment; intracellular calcium; biochemical change; morphological change; man; caspase-3; apoptosis; fibroblast; cell culture; anthracycline

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 1
• Opis fizyczny: p.121-126,fig.

Twórcy

autor

Kania K

• University of Lodz, Banacha 12-16, 90-237 Lodz, Poland

autor

Dragojew S.

autor

Jozwiak Z.

Bibliografia

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