The influence of quercetin on some biochemical parameters in rats exposed to environmental contamination with fluorine compounds

• Autorzy: Czerny B , Put A. , Mysliwiec Z. , Juzyszyn Z.
• Języki publikacji: EN

Abstrakty

EN

Male Wistar rats were exposed for 3 and 6 months to NH4F in a toxicological chamber. Some animals received sodium salts of quercetin sulfonic acids at a dose of 5 or 20 mg/kg body weight. It was found that quercetin alleviates biochemical changes in the liver caused by ammonium fluoride, in particular concerning enzyme activities and lipid metabolism.

Słowa kluczowe

EN

fluorine compound; fluoride intoxication; ammonium fluoride; environment contamination; quercetin; rat; biochemical parameter

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2000
• Tom: 09
• Numer: 3
• Opis fizyczny: p.157-161,fig.

Twórcy

autor

Czerny B

• Pomeranian Medical University, 70-111 Szczecin, Powstancow Wlkp.72, Poland

autor

Put A.

autor

Mysliwiec Z.

autor

Juzyszyn Z.

Bibliografia

• 1. VAN ACKER S.A., DE GROOT M.J., VAN DEN BERG D.J., et al. A quantum chemical explanation of the antioxidant activity of flavonoids. Chem. Res. Toxicol. 9 (8), 1305, 1996.
• 2. BLASZCZYSZYN M. Accurate and simple determination of total cholesterol in the serum. Wiad. Lek. 23 (16), 1413, 1970.
• 3. CHINOY N.J., NARAYANA M.V., SEQUEIRA E., et al. Studies on effects of fluoride in 36 villages on Mensana District, North Gujarat. Fluoride 25 (3), 101, 1992.
• 4. CHINOY N.J., SHARMA M., AHMEDABAD M.M. Beneficial effects of ascorbic acid and calcium on reversal of fluoride toxicity in male rats. Fluoride 26 (1), 45, 1993.
• 5. CHROMY V., HORNAKOVA M., BREINEK P., VROBLOVSKY P. Extractive photometric determination of serum triglycerides (in Czech). Bioch. Clin. Bohemoslov. 6, 167, 1977.
• 6. DOUSSET J.C., RIOUFOL C, PHILIBERT C, BOURBON P. Effects of inhaled HF on cholesterol, carbohydrate and tricarboxylic acid metabolism in guinea pigs. Fluoride 20 (3), 137, 1987.
• 7. ELLIOTT K.A. Tissue slice technique. W: Methods in Enzymology. Red. S.P. Colowick N.O. Kaplan. Academic Press, New York 3, 3, 1955.
• 8. FARLEY J. et al. Monofluorophosphate is hydrolyzed by alkaline phosphatase and mimics the actions of NaF on skeletal tissues in vitro. Calcif. Tissue Int. 40 (1), 35, Jan. 1987.
• 9. FORMICA J.V., REGELSON W. Review of the biology of Quercetin and related bioflavonoids. Food Chem. Toxicol. 33, 1061, 1995.
• 10. FRADA G.D., DI BIASI S., PINTACUDA S. La fluorosis. Minerva Med. 67, 75, 1976.
• 11. GRABOWSKA M., GRUMINSKA M. Wplyw fluorku sodu na ATP-azy aktywowane magnezem z bton erytrocytow ludzkich. Folia Med. Cracov. 26, 29, 1985.
• 12. GUMINSKA M. Biochemiczne mechanizmy dzialania fluoru na zywy organizm. Folia Med. Cracov. 23, 306, 1981.
• 13. HENKE J. Wartosc diagnostyczna okreslenia aktywnosci enzymow surowicy w zatruciach ostrych. Med. Pracy, 18, 61, 1967.
• 14. HINSBERG K., MERTEN R. Chemische Bestimmungsmethoden im Klinischen Laboratorium. Urban-Schwarzenberg, Miinchen, 3, 1952.
• 15. HOLLMAN P.C.H., KATAN M.B. Absorption, metabolism and health effects of dietary flavonoids in man. Biomed. Pharmacother. 51 (8), 305, 1977.
• 16. KOKOT F. Metody badan laboratoryjnych stosowanych w klinice. PZWL, Warszawa, 1969.
• 17. KUHNAU J. The flavonoids. A class of semi-essential food components, their role in human nutrition. World Review of Nutrition and Dietetitcs, 24, 117, 1976.
• 18. MACHOY Z. Biochemiczne mechanizmy dzialania zwiazkow fluoru. Folia Med. Cracov. 28, 61, 1987.
• 19. MACHOY-MOKRZYNSKA A., PUT A., CEGLECKA M., et al. Influence of essential phospholipids (EPL) on selected biochemical parameters of lipid metabolism in rats chronically exposed to ammonium fluoride vapours. Fluoride 27 (4), 201, 1994.
• 20. PEARSE A.G.E. Histochemistry. Theoretical and applied. Churchill Livingstone, Edinburgh, 1968.
• 21. PEARSE A.G.E. Histochemistry. Theoretical and applied. Churchill Livingstone, Edinburgh 1972.
• 22. PILLAI K., MATHAI A., DESHMUKH P.B. Effect of substrate dosage of fluoride on male mice. Toxicol. Lett, 44, 1, 1988.
• 23. ROBAK J., et al. The effect of some flavonoids on non-enzymatic lipid oxidation and enzymatic oxidation of arachidonic acid. Pol. J. Pharmacol., 38, 483, 1986.
• 24. RUDEL L.L., MORRIS M.D. Determination of cholesterolusing o-phtalaldehyde. J. Lipid Res., 14, 364, 1973.
• 25. SIESS M.H., et al. Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. J.Toxicol.Environ. Health, 49, 481, 1996.
• 26. STEINBERG D., et al. Beyond cholesterol modifications of low density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320, 915, 1989.
• 27. DE VRIES J.H, JANSSEN P.L, HOLLMAN P.C., VAN STAVEREN W.A., KATAN M.B. Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets. Cancer Lett. 114, 141, 1997.
• 28. WEBER H., WEGMANN T. Atlas der klinischen Enzymologie. Methoden und Arbeitsvorschriften. G. Thieme Verlag, Stuttgart 9, 13, 1968.
• 29. WESTSTONE H.J., TENNANT R., WHITE B.V. Studies on cholinesterase activity. I. Serum cholinesterase. Methods and normal values. Gastroenterology, 33, 41, 1957.
• 30. ZAKRZEWSKA H., OROWICZ W. Wplyw emisji przemyslowych zawierajacych zwiazki fluoru na profil lipidow osocza u owiec. Bromat. Chem. Toksykol. 30, 1, 49, 1997.