Is leptin what we are looking for ?

• Autorzy: Clark J. S. C. , Kielar D.
• Języki publikacji: EN

Abstrakty

EN

Leptin and its receptors are newly dicovered factors involved in regulation of energy homeostasis and body weight. Leptin is specifically produced and secreted by adipocytes, but its receptor isoforms have a wide tissue distribution and in many experiments it has been demonstrated that leptin also plays a regulatory role in hematopoiesis, development, reproduction and perhaps glucose metabolism. In this short review we summarise the recent discoveries surrounding leptin, its receptors and their genes, and discuss the possible web of interactions.

Słowa kluczowe

EN

gene therapy; leptin; leptin secretion; mice; ob gene mutation; tissue distribution; leptin level; rat; obesity; intracellular signalling; receptor; mouse; homeostasis; man; body weight; glucose metabolism; neuropeptide Y; ob gene organization

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1997
• Tom: 02
• Numer: 2
• Opis fizyczny: p.197-211,fig.

Twórcy

autor

Clark J. S. C.

• Pomeranian Medical Academy, Szczecin, Poland

autor

Kielar D.

Bibliografia

• 1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L. and Friedman J.M. Nature 372 (1994) 425-432
• 2. Pelleymounter M. A., Cullen M. J., Baker M. B., Hecht R., Winters D., Boone T. and Collins F. Science 269 (1995) 540-543
• 3. Murikami T. and Shima K. Biochem. Biophys. Res. Commun. 209 (1995) 944-952
• 4. Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M. H. and Skoda R.C. Proc. Natl. Acad. Sci. USA 93 (1996) 6231-6235
• 5. He Y., Chen H., Quon M. J. and Reitman M. J. Biol. Chem. 270 (1995) 28887-28891
• 6. Hollenberg A. N., Susulic V. S., Madura J. P., Zhang B., Moller D. E., Tontonoz P., Sarraf P., Spiegelman B. M. and Lowell B. B. J. Biol. Chem. 272 (1997) 5283-5290
• 7. Reed D. R., Ding Y., Xu W., Cather C., Green E. D. and Price R. A. Diabetes 45 (1996) 691-694
• 8. Friedman J. M. and Leibei R. L. Cell 69 (1990) 217-220
• 9. Maffei M., Stoffel M., Barone M., Moon B.,Dammerman M., Ravussin E., Bogardus C., Ludwig D. S., Flier J. S., Talley M., Auerbach S. and Friedman J. M. Diabetes 45 (1996) 679-682
• 10. Considine R. V., Considine E. L., Williams C. J., Nyce M. R., Magosin S. A., Bauer T. L., Rosato E. L., Colberg J. and Caro J. F. J. Clin. Invest. 95 (1995) 2986-2988
• 11. Clement K., Garner C., Hager J., Philippi A., LeDuc C., Carey A., Harris T. J., Jury C., Cardon L. R., Basdevant A., Devenais F., Guy- Grand North M. and Froguel P. Diabetes 45 (1996) 687-690
• 12. Halaas J. L., Gajiwala K. S., Maffei M., Cohen S. L., Chait B. T., Rabinowitz D., Lallone R. L., Burley S. K. and Friedman J. M. Science 269 (1995) 543-546
• 13. Chen G., Koyama K., Yuan X., Lee Y., Zhou Y. T., O’Doherty R., Newgard C. B. and Unger R. H. Proc. Nat. Acad. Sci. USA 93 (1996) 14795-14799
• 14. Muzzin P., Eisensmith R. C., Copeland K. C. and Woo S. L. C. Proc. Nat. Acad. Sci. USA 93 (1996) 14804-14808
• 15. Maffei M., Halaas J., Ravussin E., Pratley R. E., Lee G. H., Zhang Y., Fei H., Kim S., Lallone R. and Ranganathan S. Nature Medicine 1 (1995) 1155-1161
• 16. Lonnqvist F., Arner P., Nordfors L. and Schalling M. Nature Medicine 1 (1995) 950-953
• 17. Tartaglia L. A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G. J., Campfield L. A., Clark F. T. and Deeds J. Cell 83 (1995) 1263-1271
• 18. Lee G.-H., Proenca R., Montez J.M., Carroll K. M., Darvishzadeh J. G., Lee J. I. and Friedman J. M. Nature 379 (1996) 632-635
• 19. Cioffi J. A., Shafer A. W., Zupancic T. J., Smith-Gbur J., Mikhail A., Platika D. and Snodgrass H. R. Nature Medicine 2 (1996) 585-589
• 20. Wang M.-Y., Zhou Y. T., Newgard C. B. and Unger R. H. FEBS Lett. 392 (1996) 87-90
• 21. Considine R. V., Considine E. L., Williams C. J., Hyde T. M. and Caro J. F. Diabetes 19 (1996) 992-994
• 22. Hummel K. P., Dickie M. M. and Coleman D. L. Science 153 (1996) 1127-1128
• 23. Truett G. E., Bahary N., Friedman J. M. and Leibel R. L. Proc. Nat. Acad. Sci. USA 88 (1991) 7806-7809
• 24. Nolan J. J., Olefsky J. M., Nyce M. R., Considine R. V. and Caro J. F. Diabetes 45 (1996) 1276-1278
• 25. Slieker L. J., Sloop K. W., Surface P. L., Kriauciunas A., LaQuier F., Manetta J., Bue-Valleskey J. and Stephens T. W. J. Biol. Chem. 271 (1995) 5301-5304
• 26. Grunfeld C., Zhao C., Fuller J., Pollack A., Moser A., Friedman J. and Feingold K. R. J. Clin. Invest. 97 (1996) 2152-2157
• 27. Vidal-Puig A., Jimenez-Linan M., Lowell B. B., Hamann A., Hu E., Spiegelman B., Flier J. S. and Moller D. E. J. Clin. Invest. 97 (1996) 2553-2561
• 28. Kallen C. B. and Lazar M. A. Proc. Nat. Acad. Sci. USA 93 (1996) 5793-5796
• 29. De-Vos P., Lefebvre A. M., Miller S. G., Guerre-Millo M., Wong K., Saladin R., Hamann L.G., Staels B., Briggs M. R. and Auwerx J. J. CIin. Invest. 98 (1996) 1004-1009
• 30. Zhang B., Graziano M. P., Doebber T. W., Leibowitz M. D., White- Carrington S., Szalkowski D. M., Hey P. J., Wu M., Cullinan C. A., Bailey P., Lollmann B., Frederich R., Flier J. S., Strader C. D. and Smith R. G. J. Biol. Chem. 271 (1996) 9455-9459
• 31. Rentsch J. and Chiesi M. FEBS Lett. 379 (1996) 55-59
• 32. Hassink S. G., Sheslow D. V., de-Lancey E., Opentanova I., Considine R. V. and Caro J. F. Pediatrics 98 (1996) 201-203
• 33. Boden G., Chen X., Mozzoli M. and Ryan I. J. Clin. Endocrin. Metab. 81 (1996) 3419-3423
• 34. Sinha M. K., Ohannesian J. P., Heiman M. L., Kriauciunas A., Stephens T., Magosin S., Marco C. and Caro J. F. J. Clin. Invest. 97 (1996) 1344-1347
• 35. Frederich R. C., Hamann A., Anderson S., Lollmann B., Lowell B. B. and Flier J. S. Nature Medicine 1 (1996) 1311-1314
• 36. Rosenbaum M., Nicolson M., Hirsch J., Heymsfield S. B., Gallagher D., Chu F. and Leibel R. L. J. Clin. Endocrin. Metab. 81 (1996) 3424- 3427
• 37. Vidal H., Auboeuf D., DeVos P., Staels B., Riou J. P., Auwerx J. and Laville M. J. Clin. Invest. 98 (1996) 251-255
• 38. Ma Z., Gingerich R. L., Santiago J. V., Klein S., Smith C. H. and Landt M. Clin. Chem. 42 (1996) 942-946
• 39. Maffei M., Halaas J., Ravussin E., Pratley R. E., Lee G. H., Zhang Y., Fei H., Kim S., Lallone R. and Ranganathan S. Nature Medicine 1 (1995) 1155-1161
• 40. Klein S., Coppack S. W., Mohamed A. V. and Landt M. Diabetes 45 (1996) 984-987
• 41. Tontonez P., Hu E., Graves R. A., Budavari A. I. and Spiegelman B. M. Genes Dev. 8 (1994) 1224-1234
• 42. Gearing K. L., Gottlicher M., Widmark E., Banner C. D., Toilet P., Stromstedt M., Rafter J. J., Berge R. K. and Gustafsson J.-A. J. Nutr. 124 (1994) 1284S-1288S
• 43. Trayhurn P., Duncan J. S., Rayner D. V. and Hardie L. J. Biochem. Biophys. Res. Commun. 228 (1996) 605-610
• 44. Kosaki A., Yamada K. and Kuzuya H. Diabetes 45 (1996) 1744-1749
• 45. De Vos P., Saladin R., Auwerx J. and Staels B. J. Biol. Chem. 270 (1995) 15958-15961
• 46. Bray G. A., Fisler G. S. and Yorke D. A. Front. Neuroendocrin. 11 (1990) 128-181
• 47. Hardie L. J., Rayner D. V., Holmes S. and Trayhurn P. Biochem. Biophys. Res. Commun. 223 (1996) 660-665
• 48. Segal K. R., Landt M. and Klein S. Diabetes 45 (1996) 988-991
• 49. Kolaczynski J. W., Nyce M. R., Considine R. V., Boden G., Nolan J. J., Henry R., Mudaliar S. R., Olefsky J. and Caro J. F. Diabetes 45 (1996) 699-701
• 50. Dagogo J. S., Fanelli C., Paramore D., Brothers J. and Landt M. Diabetes 45 (1996) 695-698
• 51. Houseknecht K. L., Mantzoros C. S., Kuliawat R., Hadro E., Flier J. S. and Kahn B. B. Diabetes 45 (1996) 1638-1643
• 52. McGregor G. P., Desaga J. F., Ehlenz K., Fischer A., Heese F., Hegele A., Lammer C., Peiser C. and Lang R. E. Endocrinology 137 (1996) 1501-1504
• 53. Gainsford T., Willson T. A., Metcalf D., Handman E., McFarlane C., Ng A., Nicola N. A., Alexander W. S. and Hilton D. J. Proc. Nat. Acad. Sci. USA 93 (1996) 14564-14568
• 54. Chehab F. F., Mounzih K., Lu R. and Lim M. E. Science 275 (1997) 88-90
• 55. Barash I. A., Cheung C. C., Weigle D. S., Ren H., Kabigting E. B., Kuijper J. L., Clifton D. K. and Steiner R. A. Endocrinology 137 (1996) 3144-3147
• 56. Chehab F. F., Lim M. E. and Lu R. Nature Medicine 12 (1996) 318- 320
• 57. Lynn R. B., Cao G. Y., Considine R. V., Hyde T. M. and Caro J. F. Biochem. Biophys. Res. Commun. 219 (1996) 884-889
• 58. Malik K. F. and Young W. S. Endocrinology 137 (1996) 1497-1500
• 59. Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T. and Trayhurn P. FEBS Lett. 387 (1996) 11-116
• 60. Banks W. A., Kastin A. J., Haung W., Jaspan J. B. and Maness L. M. Peptides 17 (1996) 305-311
• 61. Caro J. F., Kolaczynski J. W., Nyce M. R., Ohannesian J. P., Opentanova I., Goldman W. H., Lynn R. B., Zhang P. L., Sinha M. K. and Considine R. V. Lancet 348 (1996) 159-161
• 62. Schwartz M. W., Peskind E., Raskind M., Boyko E. J. and Porte D. Jr. Nature Medicine 2 (1996) 589-593
• 63. Erickson J. C., Hollopeter G. and Palmiter R. D. Science 274 (1996) 1704-1707
• 64. Erickson J. C., Clegg K. E. and Palmiter R. D. Nature 381 (1996) 415- 421
• 65. Spina M., Merlo-Pich E., Chan R. K., Basso A. M., Rivier A. M., Vale W. and Koob G. F. Science 273 (1996) 1561-1564
• 66. Yinglin B., Zhang S., Kim K. S., Lee J. K. and Kim K. H. J. Biol. Chem. 271 (1996) 13939-13942
• 67. Kieffer T. J., Heller R. S. and Habener J. F. Biochem. Biophys. Res. Commun. 224 (1996) 522-527