A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin

• Autorzy: Drulis-Kawa Z , Gubernator J. , Dorotkiewicz-Jach A. , Doroszkiewicz W. , Kozubek A.
• Języki publikacji: EN

Abstrakty

EN

The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those of the free drug.

Słowa kluczowe

EN

liposome; gentamicin; drug; cationic formulation; meropenem; bacteria; in vitro; antimicrobial activity; serum medium

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2006
• Tom: 11
• Numer: 3
• Opis fizyczny: p.360-375,fig.,ref.

Twórcy

autor

Drulis-Kawa Z

• University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland

autor

Gubernator J.

autor

Dorotkiewicz-Jach A.

autor

Doroszkiewicz W.

autor

Kozubek A.

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