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1998 | 45 | 2 |

Tytuł artykułu

Implication of glycolipids in lens fiber development

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Mammalian lens contains Lewisx, sialyl-Lewisx and α-galactosyl epitopes in neolacto-series glycosphingolipids. The expression of these three epitopes is not observed in lens epithelial cells, but is immunohistochemically detected in the inner cortical fibers and the lens nucleus. In embryonic chick lens, sialyl-Lewisx-containing gangliosides were also detected in the transitional zone and elongating lens fibers. Thus, the Lewisx, sialyl-Lewisx and α- galactosyl epitopes may be associated with the differentiation and maturation of lens epithelial cells to lens fibers.

Wydawca

-

Rocznik

Tom

45

Numer

2

Opis fizyczny

p.501-507,fig.

Twórcy

autor
  • Tokyo Institute of Technology, Yokohama 226-8501, Japan

Bibliografia

  • Bloemendal, H. (1977) The vertebrate eye lens. A useful system for the study of fundamental biological processes on a molecular level. Sci­ence 197. 127-138.
  • Chylack, L.T. (1984) Mechanisms of senile cata­ract formation. Ophthalmology 91, 596-602.
  • Galili, U., Clark, M.R., Shohet, S.B., Buehler, J. & Macher, B.A. (1987) Evolutionary relationship between the natural anti-Gal antibody and the Galal-3Gal epitope in primates. Proc. Natl. Acad. Sci. U.S.A. 84, 1369-1373.
  • Galili, U., Shohet, S.B., Kobrin, E., Stults, C.L.M. & Macher, B.A. (1988) Man, apes, and Old World monkeys differ from other mammals in the expression of «-galactosyl epitopes on nu­cleated cells. J. Biol Chem. 263,17755-17762.
  • Hendricks, S.P., He, P., Stults, C.L.M. & Macher, B.A. (1990) Regulation of the expression of Gak*l-3GaI/?l-4GlcNAc glycosphingolipids in kidney. J. Biol. Chem. 265, 17621-17626.
  • IUPAC-IUB Commission on Biochemical Nomen­clature. (1977) The nomenclature of lipids. Lipids 12, 455-463.
  • Maisel, H., Harding, C.V., Alcalá, J.A., Kuszak, J. & Bradley, R. (1981) The morphology of the lens; in MolfiCidar and Cellular Biology of the Eye Lens (Bloemendal, H. ed.) pp. 49-84, John Wiley & Sons Inc., New York.
  • Ogiso, M., Irie, A., Kubo, H., Hoshi, M. & Komoto, M. (1992) Senile cataractrrelated accumula­tion of Lewis* glycolipid in human lens. J. Biol Chem. 267, 6467-6470.
  • Ogiso, M., Irie, A., Kubo, H., Komoto, M., Matr suno, T., Koide, Y. & Hoshi, M. (1993) Charac­terization of neutral glycosphingolipids in hu­man cataractous lens. J. Biol. Chem. 268, 13242-13247.
  • Ogiso, M., Okinaga, T., Komoto, M., Nishiyama, I. & Hoshi. M. (1994a) Comparative study of gly- cosphingolipid composition in mammalian lenses. Exp. Eye Res. 59, 653-664.
  • Ogiso, M., Ohta, M., Okinaga, T., Hoshi, M., Ko­moto, M., Asano, K. & Takehana, M. (1994b) Glycosphingolipids in cultured lens epithelial cells from dcg and rhesus monkey. Glyco- biology 4, 375-382.
  • Ogiso, M., Okinaga, T., Ohta, M., Komoto, M. & Hoshi, M. (1995) Identification and synthetic pathway of sialyl-Lewisx-containing neolacto- series gangliosides in lens tissues. 1. Charac­terization of gangliosides in human senile cataractous lens. Biochim. Biophys. Acta 1256, 166-174.
  • Ogiso, M., Shogomori, H. & Hoshi, M. (1998a) Lo­calization of Lewisx, sialyl-Lewis* and «-galact osyl epitopes on glycosphingolipids in lens tis­sues. Glycobiology 8. 95-105.
  • Ogiso, M., Takehana, M., Kobayashi, S. & Hoshi, M. (1998b) Expression of sialylated Lewis* gangliosides in cultured lens epithelial cells from rhesus monkey. Exp. Eye Res. (in press).
  • Svennerholm, L. (1964) The gangliosides. J. Lipid Res. 5, 145-162.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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