The selected pathophysiological aspects of PPARs activation

• Autorzy: Kiec-Wilk B. , Dembinska-Kiec A. , Olszanecka A. , Bodzioch M. , Kawecka-Jaszcz K.
• Języki publikacji: EN

Abstrakty

EN

Peroxisome proliferator activated receptors (PPARs) belong to a subfamily of transcription nuclear factors. Three isoforms of PPARs have been identified: alpha, ß/ and , encoded by different genes and distributed in various tissues. They play important roles in metabolic processes like regulation of glucose and lipid redistribution. They also have anti-atherogenic, anti-inflammatory as well as anti-hypertensive functions. In hypertension-induced cardiac hypertrophy, both PPARalpha and PPAR activation reveal cardio-protective effect. Despite these beneficial functions, several recent experimental reports point to the possibille unfavorable effects of PPARs activation in lipid metabolism (lipotoxicity) in cardiomyocytes, which can lead to pathologic cardiac hypertrophy in such diseases as diabetes type 2, metabolic syndrome or obesity. This paper reviews evidences and hypotheses about the new pathophysiological aspects of PPARs activation.

Słowa kluczowe

EN

lipotoxicity; transcription nuclear factor; diabetes mellitus; hypertension; heart hypertrophy; peroxisome proliferator-activated receptor

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2005
• Tom: 56
• Numer: 2
• Opis fizyczny: p.149-162,fig.,ref.

Twórcy

autor

Kiec-Wilk B.

• Medical College Jagiellonian University, Kopernika 15a, 30-504 Krakow, Poland

autor

Dembinska-Kiec A.

autor

Olszanecka A.

autor

Bodzioch M.

autor

Kawecka-Jaszcz K.