Interaction of class A G protein-coupled receptors with G proteins

• Autorzy: Slusarz R. , Ciarkowski J.
• Języki publikacji: EN

Abstrakty

EN

A model for interaction of class A G protein-coupled receptor with the G protein Ga subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gta C-terminal peptide bound to RD* while stabilizing it. As­suming the interactions involve conserved parts of the partners, the model specifies the conserved Helix 2 non-polar X- - -X, Helix 3 DRY and Helix 7/8 NP- -Y- - F RD* mo­tifs interacting with the Gta C-terminal peptide, in compliance with the structure of the latter. A concomitant role of Gta and Gtγ C-termini in stabilizing RD* could po­ssibly be resolved assuming a receptor dimer as requisite for G protein activation.

Słowa kluczowe

EN

transmembrane; G protein; interaction; G protein-coupled receptor; membrane protein

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 1
• Opis fizyczny: p.129-136,fig.,ref.

Twórcy

autor

Slusarz R.

• University of Gdansk, J.Sobieskiego 18, 80-952 Gdansk, Poland

autor

Ciarkowski J.

Bibliografia

• Archer E, Maigret B, Escrieut C, Pradayrol L, Fourmy D. (2003) Trends Pharmacol Sci.; 24: 36-40.
• Altenbach C, Klein-Seetharaman J, Cai K, Khorana HG, Hubell WL. (2001) Biochemistry.; 40: 15493-500.
• Arimoto R, Kisselev OG, Makara GM, Marshall GR. (2001) Biophys J.; 81: 3285-93.
• Aris L, Gilchrist A, Rens-Domiano S, Meyer C, Schatz PJ, Dratz EA, Hamm HE. (2001) J Biol Chem.; 276: 2333-9.
• Ballesteros J, Palczewski K. (2001) Curr Opin DrugDiscovDevel.; 4: 561-74. Ballesteros JA, Shi L, Javich JA. (2001) Mol Pharmacol.; 60: 1-19.
• Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE. (2000) Nucleic Acids Res.; 28: 235-42.
• Bissantz C, Bernard P, Hibert M, Rognan D. (2003) Proteins.; 50: 5-25.
• Bourne PE. (2000) Nucleic Acids Res.; 28: 235-42.
• Bourne HR. (1997) Curr Opin Cell Biol.; 9: 134-42.
• Case DA, Pearlman DA, Caldwell JW, Cheatham III TE, Ross WS, Simmerling C, Darden T, Merz KM, Stanton RV, Cheng A, Vincent JJ, Crowley M, Ferguson DM, Radmer R, Seibel GL, Singh UC, Wiener P, Kollman PA. (1997) Amber 5.0. University of California San Francisco.
• Cherfils J, Chabre M. (2003) Trends Biochem Sci.; 28: 13-7.
• Ernst OP, Meyer CK, Marin EP, Henklein P, Fu WY, Sakmar TP, Hofmann KP. (2000) J Biol Chem.; 275: 1937-43.
• Fahmy K, Jager F, Beck M, Zvyaga TA, Sakmar TP, Siebert F. (1993) Proc Natl Acad Sci USA.; 90: 10206-10.
• Farrens DL, Altenbach C, Yang K, Hubell WL, Khorana HG. (1996) Science.; 274: 768-78.
• Filipek S, Teller DC, Palczewski K, Stenkamp R. (2003a) Annu Rev Biophys Biomol Struct.; 32: 375-97.
• Filipek S, Stenkamp R, Teller DC, Palczewski K. (2003b) Annu Rev Physiol.; 65: 851-79.
• Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. (2003) Nature.; 421: 127-8.
• Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. (2003) Proc Natl Acad Sci US A.; 100: 2290-5.
• George SR, O'Dowd BF, Lee SP. (2002) Nat Rev Drug Discov.; 1: 808-20. Guex N, Diemand A, Peitsch MC. (1999) Trends Biochem Sci.; 24: 364-7.
• van Gunsteren WF, Berendsen HJC. (1996) Biomolecular Simulation: the GROMOS96 Manual and User Guide. Vdf Hochschulverlag ETH Zurich. (http://www.igc.ethz.ch/gromos/).
• Hamm HE. (2001) Proc Natl Acad Sci U S A.; 98: 4819-21.
• Hamm HE, Deretic D, Arendt A, Hargrave PA, Konig B, Hoffman KP. (1988) Science.; 241: 832-5.
• Hunyady L, Vauquelin G, Vanderheyden P. (2003) Trends Pharmacol Sci.; 24: 81-6.
• Iiri T, Fartel Z, Bourne H. (1998) Nature.; 394: 35-8.
• Jorgensen WL, Tirado-Rives J. (1988) J Am Chem Soc.; 110: 1657-66.
• Kisselev OG. Downs MA. (2003) Structure.; 11: 367-73.
• Kisselev OG, Kao J, Ponder JW, Fann YC, Gautam N, Marshall GR. (1998) Proc Natl Acad Sci US A.; 95: 4270-5.
• Kisselev OG, Meyer CK, Heck M, Ernst OP, Hoffman KP. (1999) Proc Natl Acad Sci USA.; 96: 4898-903. Klabunde T, Hessler G. (2002) ChemBioChem.; 3: 928-44. Koenig BW. (2002) ChemBioChem.; 3: 975-80.
• Koenig B.W, Kontaxis G, Mitchell DC, Louis JM, Litman BJ, Bax A. (2002) J Mol Biol.; 322: 441-61.
• Lambright DG, Noel JP, Hamm HE, Sigler PB. (1994) Nature.; 369: 621-8.
• Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. (1996) Nature.; 379: 311-9.
• Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A. (2003) J Biol Chem.; 278: 21655-62.
• Lu Z-L, Saldanh JW, Hulme EC. (2002) Trends Pharmacol Sci.; 23: 140-6.
• Martin EL, Rens-Domiano S, Schatz PJ, Hamm HE. (1996) J Biol Chem.; 271: 361-6.
• Mirzadegan T, Benko G, Filipek S, Palczewski K. (2003) Biochemistry.; 42: 2759-67.
• Miyano M. (2001) Pharmacogenomics J; 1: 225-8.
• Meng EC, Bourne H. (2001) Trends Pharmacol Sci.; 22: 587-93.
• Noel JP, Hamm HE, Sigler PB. (1993) Nature.; 366: 654-63.
• Okada T, Palczewski K. (2001) Curr Opin Struct Biol. ; 11: 420-6.
• Okada T, Ernst OP, Palczewski K, Hofmann KP. (2001) Trends Biochem Sci.; 26: 318-24.
• Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y. (2002) Proc Natl Acad Sci U S A.; 99: 5982-7.
• Oliveira L, Paiva ACM, Vriend G. (1999) Protein Eng.; 12: 1087-95.
• Onrust R, Herzmark P, Chi P, Garcia PD, Lichtarge O, Kingsley C, Bourne HR. (1997) Science.; 275: 381-4.
• Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyamoto M. (2000) Science.; 289: 739-45.
• Rohrig UF, Guidoni L, Rothlisberger U. (2002) Biochemistry.; 41: 10799-809.
• Sakmar TP. (2002) Curr Opin Cell Biol.; 14: 189-95.
• Saam J, Tajkhorshid E, Hayashi S, Schulten K. (2002) Biophys J.; 83: 3097-112. Stenkamp RE, Teller DC, Palczewski K. (2002) ChemBioChem.; 3: 963-7. SYBYL 6.6(1999) Tripos Inc. 1699 South Hanley Rd, St. Louis MO 63144 U S A.
• Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. (2002) Biochemistry.; 40: 7761-72.