Glycosylation defects corrected by the changes in GDPmannose level

• Autorzy: Kruszewska J. , Janik A. , Lenart U. , Palamarczyk G.
• Języki publikacji: EN

Abstrakty

EN

GDPMan is a key substrate in glycoprotein formation. This is especially true for lower eukaryotes where, in addition to the involvement in N-glycan biosynthesis and GPI-anchor formation, GDPMan takes part in the process which is unique for yeast and fungi i.e. O-mannosylation. Several lines of evidence have been presented that the level of GDPMan affects the process occurring in the Golgi compartment i.e. the elongation of outer mannose chain of glycoproteins in Saccharomyces cerevisiae. Results from our laboratory indicate that the availability of GDPMan affects also the early steps of glycoprotein formation ascribed to the endoplasmic reticulum, i.e. assembly of the dolichol-linked oligosaccharide as well as mannosyl-phosphodolichol (MPD) formation. The biochemical basis of carbohydrate deficient glycoprotein syndrome, a severe neurological disorder related to the GDPMan deficiency, is also discussed.

Słowa kluczowe

EN

yeast; glycoprotein formation; carbohydrate deficient glycoprotein syndrome; Golgi apparatus; N-glycan biosynthesis; mannose chain; dolichol; GDPmannose; protein glycosylation; Saccharomyces cerevisiae

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 2
• Opis fizyczny: p.315-324,fig.

Twórcy

autor

Kruszewska J.

• Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland

autor

Janik A.

autor

Lenart U.

autor

Palamarczyk G.

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