Zmiany patologiczne watroby w inwazji przywry Fasciola hepatica

• Autorzy: Gajewska A , Smaga-Kozlowska K. , Wisniewski M.
• Języki publikacji: PL

Abstrakty

EN

Pathological changes of liver in infection of Fasciola hepatica. Fasciolosis caused by Fasciola hepatica is a hepatic parasitic infection that affects numerous mammal species, mainly ruminants, in several countries of Europe, Asia and America. The economic significance of fasciolosis is mainly due to direct losses caused by a decrease of weight rate, milking capacity and the confiscation of altered livers in slaughterhouse. In this review we present mechanisms of damaging of host liver during invasion of Fasciola hepatica. Parasites digest hepatic tissue and cause extensive parenchymal destruction with intensive haemorrhagic lesions and immunological reactions. Mechanical liver damage is due to migrating juvenile fluke. Macerated hepatic cells have been observed inside the oral sucker and pharynx. Moreover, the process of ulceration of liver tissue was observed in regions adjacent to the spiny body of fluke tegument. On the other hand, the injury of the liver can be induced chemically by factors produced or induced by the fluke. Probably, fluke proteases and other tissue-degrading enzymes can be responsible for negative effect on liver parenchyma. There is no evidence to link fluke-enzymes with tissue penetration. The consequences of liver damage resulting from the migrating flukes compromises liver function which is reflected in changes of plasma protein concentration (albumin, globulin). Additianally, changes of levels of hepatic enzymes released into the blood as a result of damage of liver tissue are used to monitor the progress of the infection in a variety of Fasciola hepatica hosts and as a sensitive diagnostic aid in field infection.

Słowa kluczowe

PL

przywry; Fasciola hepatica; parazytologia; pasozyty; inwazja pasozytnicza; watroba; zmiany patologiczne

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2005
• Tom: 51
• Numer: 2
• Opis fizyczny: s.115-123,tab.,bibliogr.

Twórcy

autor

Gajewska A

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Ciszewskiego 8, 02-786 Warszawa

autor

Smaga-Kozlowska K.

autor

Wisniewski M.

Bibliografia

• [1] Ross J.G., Todd J.R., Dow C. 1966. Single experimental infections of calves with the liver fluke Fasciola hepatica (Linnaeus 1758). Journal of Comparative Pathology 76: 67-81.
• [2] Sinclair K.B. 1967. Pathogenesis of Fasciola and other liver-flukes. Helminthological Abstracts 36: 115-134.
• [3] Dow C., Ross J.G., Todd J.R. 1967. The pathology of experimental fascioliasis in calves. Journal of Comparative Pathology 77: 377-385.
• [4] Boray J.C. 1969. Experimental fascioliasis in Australia. Advances in Parasitology 7: 95-209.
• [5] Kendall S.B., Parfitt J.W. 1962. The chemotherapy of fascioliasis. British Veterinary Journal 118: 1-10.
• [6] Dawes B., Hughes D.L. 1964. Fascioliasis: the invasive stages of Fasciola hepatica in mammalian hosts. - Advances in Parasitology 2: 97-168.
• [7] Dawes B., Hughes D.L. 1970. Fascioliasis: the invasive stages in mammals. Advances in Parasitology 8: 259-274.
• [8] Angielski S., Rogulski J. 1991. Biochemia kliniczna, PZWL, Warszawa.
• [9] Stefański W. 1968. Parazytologia weterynaryjna. Tom I, Protozologia i hemintologia. PWRiL, Warszawa.
• [10] Sukhdeo M.V., Sangster N.C., Mettrick D.F. 1988. Permanent feeding sites of adult Fasciola hepatica in rabbits? International Journal for Parasitology 18: 509-512.
• [11] Dawes B. 1963. Some observations of Fasciola hepatica L. during feeding operations in the hepatic parenchyma of the mouse, with notes on the nature of liver damage in this host. Parasitology 53: 135-143.
• [12] Dawes B. 1963. Hyperplasia of the bile duet in fascioliasis and its relation to the problem of nutrition in the liver-fluke, Fasciola hepatica L. Parasitology 53: 123-133.
• [13] Isseroff H., Girard P.R., Leve M.D. 1977. Fasciola hepatica: bile duet enlargement induced in rats after intraperitoneal transplantation. Experimental Parasitology 41: 405-409.
• [14] Modavi S., IsseroffH. 1984. Fasciola hepatica: collagen deposition and other histopathology in the rat host's bile duet caused by the parasite and by proline infuzion. Experimental Parasitology 58: 239-244.
• [15] Tort J., Brindley P.J., Knox D., Wolfe K.H., Dalton J.P. 1999. Proteinases and associated genes of para-121 sitic helmints. Advances in Parasitology 43: 161-265.
• [16] Spithill T.W., Dalton J.P. 1998. Progress in development of liver fluke vaccines. Parasitology Today 14: 224- 228.
• [17] Kofta W., Mieszczanek J., Plucienniczak G., Wedrychowicz H. 2000. Successful DNA immunisation of rats against fasciolosis. Vaccine 18: 2985-2990.
• [18] Wędrychowicz H., Lamparska M., Kesik M., Kotomski G., Mieszczanek J., Jedlina-Panasiuk L., Plucienniczak A. 2003. The immune response of rats to vaccination with the cDNA or protein forms of the cysteine proteinase of Fasciola hepatica. Veterinary Immunology and Immunopathology 94: 83-93.
• [19] Bozas S.E., Panaccio M., Creaney J., Dosen M., Parsons J.C., Vlasuk G.V., Walker L.D., Spithill T.W. 1995. Characterisation of a novel Kunitz-type molecule from the trematode Fasciola hepatica. Molecular and Biochemical Parasitology 74: 19-29.
• [20] Jennings F.W. 1976. The anaemias ofparasitic infections. In: Pathophysiology of Parasitic Infection, (Ed. E.J.L. Soulsby), Academic Press, New York: 41-67.
• [21] Dargie J.D., Mulligan W. 1970. Ferrokinetic studies on normal and fluke-infected rabbits. Journal of Comparative Pathology 80: 37-45.
• [22] Eriksen L. 1980. Fasciola hepatica: influence of thymus function on the liver pathology in mice. Nordisk Veterinaermedicin 32: 493-500.
• [23] Anderson P.H., Berrett S., Brush P.J., Hebert C.N., Parfitt J.W., Patterson D.S. 1977. Biochemical indicators of liver injury in calves with experimental fascioliasis. Veterinary Record 100: 43-45.
• [24] Dargie J.D. 1981. Blood protein tumover in parasitized ruminants. In: Isotopes and Radiation in Parasitology IV. International Atomie Energy Agency, Vienna: 155-170.
• [25] Symons LE.A. 1989. Pathophysiology of Endoparasitic Infection. Academic Press, Sydney.
• [26] Dargie J.D., Mulligan W. 1971. The onset and development of anaemia and hypoalbuminaemia in rabbits infected with Fasciola hepatica. Journal of Comparative Pathology 81: 187-202.
• [27] Thorpe E. 1965. Liver damage and the host-parasite relationship in experimental fascioliasis in the albino rat. Research in Veterinary Science 6: 498-509.
• [28] Holmes P.H., Dargie J.D., MacLean J.M., Mulligan W. 1968. Albumin and globulin tumover in chronic ovine fascioliasis. Veterinary Record 83: 227-228.
• [29] Sinclair K.B. 1968. The effect of corticosteroid on the plasma protein of lambs infected with Fasciola hepatica. Research in Veterinary Science 9: 181-183.
• [30] Sinclair K.B. 1970. The effect of splenectomy on the pathogenicity of Fasciola hepatica in the sheep. British Veterinary Journal 126: 15-29.
• [31] Berry C.I., Dargie J.D. 1976. The role of host nutrition in the pathogenesis of ovine fascioliasis. Veterinary Parasitology 2: 317-332.
• [32] Sykes A.R., Coop R.L., Rushton B. 1980. Chronic subclinical fascioliasis in sheep: effects on food intake, food utilisation and blood constituents. Research in Veterinary Science 28: 63-70.
• [33] Hughes D.L., Hanna R.E., Symonds H.W. 1981. Fasciola hepatica: IgG and IgA levels in the serum and bile of infected cattle. Experimental Parasitology 52: 271-279.
• [34] Poitou I., Baeza E., Boulard C. 1992. Humoral and cellular immune responses in rats during a primary infestation with Fasciola hepatica. Veterinary Parasitology 45: 59-71.
• [35] Jemli M.H., Braun J.P., Dorchies P., Romdhane M.N., Kilani M. 1993. Exploration biochimique et hematologique chez l'agneau infeste experimentalement par Fasciola hepatica. Recueil de Medecine Veterinaire 169: 241-249.
• [36] Sinclair K.B. 1973. The resistance of sheep to Fasciola hepatfca: studies on the development and pathogenicity of challenge infections. British Veterinary Journal 129: 236-250.
• [37] Hughes D.L., Treacher R.J., Harness E. 1973. Plasma enzyme changes in goats infected with Fasciola hepatica and the effest of nitroxynil. Research in Veterinary Science 15: 249-255.
• [38] Schuster J., Lammler G. 1973. Fasciola hepaticalnfektion der Albinoratte I. Untersuchungen zur Entwicklung und Pathophysiologie. Zeitschrift für Parasitenkunde 41: 311-326.
• [39] Rowlands D.T., Clampitt R.B. 1979. Plasma enzyme levels in ruminants infected with Fasciola hepatica. Veterinary Parasitology 5: 155-175.
• [40] Rajasekariah G.R., Howell M.J. 1980. Enzyme assay for detecting resistance to reinfection with the liver fluke Fasciola hepatica in rats. Research in Veterinary Science 29: 124-125.
• [41] Ferre I., Barrio J.P., Gonzalez-Gallego J., RojoVazquez F.A. 1994. Appetite depression in sheep experimentally infected with Fasciola hepatica L. Veterinary Parasitology 55: 71-79.
• [42] Ferre I., López P., Rojo-Vazquez F.A., Gonzalez-Gallego J. 1996. Experimental ovine fasciolosis - antipyrine clearance as indicator of liver damage. Veterinary Parasitology 62: 93-100.
• [43] Anderson P.H., Matthews J.G., Berrett S., Brush P.J., Patterson D.S.P. 1981. Changes in plasma enzyme activity and other blood components in response to acute and chronic liver damage in cattle. Research in Veterinary Science 31: 1-4.
• [44] Sandeman R.M., Howell M.J. 1981. Response of sheep to challenge infection with Fasciola hepatica. Research in Veterinary Science 30: 294-297.
• [45] Bulgin M.S., Anderson B.C., Hall R.F., Lang B.Z. 1984. Serum gamma glutamyl transpeptidase activity in cattle with induced fascioliasis. Research in Veterinary Science 37: 167-171.
• [46] Marley S.E., Corwin R.M., Hutcheson D.P. 1996. Effect of Fasciola hepatica on productivity of beef steers from pasture through feedlot. Agri-Practice 17: 18-23.
• [47] Sinclair K.B. 1975. The resistance of sheep to Fasciola hepatica: studies on the pathophysiology of challenge infections. Research in Veterinary Science 19: 296-303.
• [48] Poitou I., Baeza E., Boulard C. 1993. Analysis of the results obtained using a tech.nic of experimental primary infestation with Fasciola hepatica in the rat. International Journal for Parasitology 23: 403-406.
• [49] Gonzalez P., Tunon M.J., Lopez P., Diez N., Gonzalez J. 1991. Hepatic disposition of organie anions in rats infested with Fasciola hepatica. Experimental Parasitology 73: 396-402.
• [50] Prache S., Galtier P. 1990. Evolution de la bilirubinemie et de l'activite plasmatique de la g-glutamyl transferase chez des agneaux infestes experimentalement par Fasciola hepatica. Reproduction, Nutrition et Developpement 2: 233-234.
• [51] Ferre I., López P., Gonzalo-Orden M., Julian M.D., Rojo-Vazquez F.A., Gonzalez-Gallego J. 1995. The effects of subclinical fasciolosis on hepatic secretory function in sheep. Parasitology Research 81: 127-131.
• [52] Lopez P., Gonzalez P., Tunon M.J., Gonzalez-Gallego J. 1994. The effects of experimental fasciolosis on bilirubin metabolism in the rat. Experimental Parasitology 78: 386-393.
• [53] Symonds H.W., Mathe D.L., Mallinso C.B., Hughes D.L. 1983. Bile flow, bile salt secretion and the excretion of iron, copper, zinc and manganese in the bile of calves infested with Fasciola hepatica. Research in Veterinary Science 35: 69-74.
• [54] Gameel A.A. 1982. Plasma ascorbic acid levels in sheep experimentally infected with Fasciola hepatica. Zeitschrift für Parasitenkunde 66: 321-326.
• [55] Kouider S.A., Kolb E. 1994. Der Gehalt an Ascorbinsäure, an Glucose, an Gesamtprotein, an ALAT und an ASAT im Blutplasma von gesunde Schafen sowie bei solchen mit Parasitenbefall vor und nach i.v. Injektion von Ascorbinsaurelösung. Monatshefte für Veterinärmedizin 49: 135-141.
• [56] Maffei Pacino R., Carini M., Genchi C., Tofanetti O., Casciarri I., Bedosch D. 1990. Antihepatotoxic properties of uridine-diphosphoglucose in liver fluke infection. Arzneimittel-Forschung/Drug Research 40: 490-198.
• [57] Maffei Pacino R., Carini M., Aldini G., Ceserani R., Casciarri I., Cavalletti E., Verderio L. 1993. Efficacy of glutathione for treatment of fascioliasis - an investigation in the experimentally infested rat. Arzneimittel-Forschung/Drug Research 43: 455-460.
• [58] Galtier P., Vandenberghe Y., Coecke S., Eeckhoutte C., Larrieu G., Vercruysse A. 1991. Differential inhibition of rat hepatic glutathione S-transferase isoenzymes in the course of fascioliasis. Molecular and Biochemical Parasitology 44: 255-260.
• [59] Lenton L.M., Behm C.A., Bygrave F.L. 1995. Aberrant mitochondrial respiration in the livers of rats infected with Fasciola hepatica: the role of elevated non-esterified fatty acids and altered phospholipid composition. Biochemical Journal 307: 425-431.
• [60] Gameel A.A. 1982. Tissue ascorbic acid concentrations in rats experimentally infected with Fasciota hepatica. Zeitschrift für Parasitenkunde 68: 181-184.