Immunotherapy in Gram-negative bacterial infections

• Autorzy: Lugowski C.
• Języki publikacji: EN

Abstrakty

EN

Endotoxins are responsible for initiation of septic shock which increases the number of fatalities in Gram-negative bacteremia among hospital patients. The morality from septic shock is still high despite recent developments in antibiotic therapy because antibiotics are unable to decrease the level of free lipopolysaccharide in the blood stream. Another approach to the treatment and prevention of septicaemia involves stimulation of an immune response against LPS. It was found that immunization with the core structures of endotoxin conjugated with proteins protected animals against infections and endotoxic shock. Anticonjugate sera are of great interest because they are directed against conserved parts of LPS and therefore could have cross-reactive and cross-protective properties with respect to many Gram-negative rods.

Słowa kluczowe

EN

Gram-negative bacterium; antibiotic therapy; vaccine; bacterial infection; immunotherapy; oligosaccharide core; endotoxin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 1
• Opis fizyczny: p.19-24,fig.

Twórcy

autor

Lugowski C.

• Polish Academy of Sciences, Czerska 12, 53-114 Wroclaw, Poland

Bibliografia

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