Effects of pre- and postnatal zinc exposure on adult rat brain dopamine activity and behavior

• Autorzy: Nowak P , Bielaczyc G. , Szkilnik R. , Labus L. , Dabrowska J. , Bortel A. , Szczerbak G. , Swoboda M. , Kwiecinski A. , Brus R.
• Języki publikacji: EN

Abstrakty

EN

Pregnant Wistar rats received 50 ppm of zinc (ZnSO4 • 7H2O) in their drinking water for the entire duration of pregnancy. On the day of delivery zinc was removed from the drinking water. Another group, dams, received 50 ppm of zinc in drinking water during the suckling period (from delivery until the 21st day of postnatal life). Their offspring were weaned on the 21st day, at which time zinc was removed from the drinking water. The control group drank tap water only. In 8-12-week-old offspring of all three groups the DA, DOPAC, HVA, 3-MT, 5-HT, 5-HIAA, NA, and MOPEG synthesis rate in the brain was estimated by HPLC/ED technique. Independent behavioral exam were performed such as locomotor and exploratory activity, irritability, yawning and oral activity, stereotype behavior, catalepsy and others. For the above, cen­tral DA receptor agonists (quinpirole, SKF 38393, apomorphine, 7-OH-DPAT) or antagonists (haloperidol, SCH 23390) were used. It was found that exposure to zinc during early stages of ontogenic development produce changes in the central dopaminergic system activity of adult offspring. From the above we con­cluded that uncontrolled supplementation with zinc during pregnancy or lactation can induce disturbance of the central dopaminergic system in adult mammal.

Słowa kluczowe

EN

behaviour; adult rat; postnatal exposure; biogenic amine; prenatal exposure; brain; dopamine activity; zinc; exposure; rat

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2006
• Tom: 15
• Numer: 4
• Opis fizyczny: p.565-572,fig.,ref.

Twórcy

autor

Nowak P

• Medical University of Silesia, Jordana 38, 41-808 Zabrze, Poland

autor

Bielaczyc G.

autor

Szkilnik R.

autor

Labus L.

autor

Dabrowska J.

autor

Bortel A.

autor

Szczerbak G.

autor

Swoboda M.

autor

Kwiecinski A.

autor

Brus R.

Bibliografia

• 1. GOYER R.A. Toxic effect of metals. In: Casarett and Doull's Toxicology - The Basic Science of Poisoning (Amdur M.O., Doull J., Klassen C.D., eds.), Pergamon Press, pp. 623-680, 1991.
• 2. DAVIES N.T. Studies on absorption of zinc by rat intestine. Br. J. Nutr. 43, 189, 1980.
• 3. CLEGG M.S., KEEN C.C., HURLEY L.S. Biochemical pa­thologies of zinc deficiency. In: Zinc in Human Biology (Mills C.F., ed.), Springer-Verlag, New York, pp. 129-145, 1989.
• 4. FURST A. Bioassay of metals for carcinogenesis: whole animals. Environ. Health Perspect. 40, 83, 1984.
• 5. pRASAD A.S. Clinical manifestation of zinc deficiency. Ann. Rev. Nutr. 5, 341, 1985.
• 6. LIN A.M.Y. Coexistence of zinc and iron augmented oxida­tive injuries in the nigrostriatal dopaminergic system of SD rats. Free Rad. Biol. Med. 30, 225, 2001.
• 7. KiM Y.H., KiM E.Y., GWAG B.J., SOHN S., KOH J.Y. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals. Neurosci. 89, 175, 1999.
• 8. DiNELEY K.E., RiCHARDS L.L., VOTYAKOVA TV., REYNOLDS i.J. Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochon­dria. Mitochondrion 5, 55, 2005.
• 9. LO H.S., CHiANG H.C, LiN A.M., CHiANG H.Y., CHU Y.C., KAO L.S. Synergistic effects of dopamine and Zn2+ on the induction of PC12 cell death and dopamine depletion in the striatum: possible implication in the pathogenesis of Parkinson's disease. Neurobiol. Dis. 17, 54, 2004.
• 10. dexter D.t, WELLS F.R., LEES A.J., AGiD F., AGiD Y., JENNER p., MARSDEN C.D. Increased nigral iron con­tent and alteration in other metal ions occuring in brain in parkinson's disease. J. Neurochem. 52, 1830, 1989.
• 11. LAND p.W., ALiZENMA N.E. Zinc accumulation after tar­get loss: an early event in retrograde degeneration of tha- lamic neurons. Eur. J. Neurosci. 21, 647, 2005.
• 12. RICHFIELD E.K. Zinc modulation of drug binding, cocaine affinity states and dopamine uptake on the dopamine uptake complex. Mol. Pharmacol. 43, 100, 1992.
• 13. TUOMiSTO J., KOMULAiNEN H. Ca-dependence of accu­mulation of monoamines into synaptosomes and its inhibition by copper. Acta Pharmacol. Toxicol. 53, 193, 1983.
• 14. LOLAND C.J., NORREGAARD L., GETHER U. Defining proximity relationships in the tertiary structure of the do- pamine transporter. identification of a conserved glutaminic acid as a third coordinate in the endogenous Zn (2+)-binding site. J. Biol. Chem. 274, 36928, 1999.
• 15. NORGAARD-NiELSEN K., NORREGAARD L., HAS­TRUp H., JAViTCH J.A., GETHER U. Zn(2+) site engi­neering at the oligometric interfere of the dopamine trans­porter. FEBS Lett. 524, 87, 2002.
• 16. SCHOLZE p., NORREGAARD L., SiNGER E.A., FRE- iSSMUTH M., GETHER U., SiTTE H.H. The role of zinc ion in reverse transport mediated by monoamine transport­ers. J. Biol. Chem. 277, 21505, 2002.
• 17. EGASHiRO T., TAKAYAMA F., SAKAi K. Effects of zinc ion on type A monoamine oxidative in monkey brain mito­chondria. Biochem. Pharmacol. 65, 625, 2000.
• 18. DEVRiES D.J., BEART p.M. Competitive inhibition of (3H)spiperone binding to D-2 dopamine receptors in striatal homogenates by organic calcium channel antagonists and polyvalent cations. Eur. J. pharmacol. 106, 133, 1983.
• 19. HAZELHOFF-ROELFZEMA W.H., ROELFSEN A.M., LEENE W., COpiUS pEEREBOOM-STEGEMAN J.H.J. Effect of cadmium exposure during pregnancy on cadmium and zinc concentration in neonatal liver and consequences for the offsprings. Arch. Toxicol. 63, 38, 1989.
• 20. MUTCH P.B., HURLEY L.S. Effect of zinc deficiency dur­ing lactation on postnatal growth and development of rats. J. Nutr. 104, E26, 1974.
• 21. ROMEO I.A., ABBOTT N.J., BRADBURY M.W.B. The blood-brain barrier in normal CNS and in metal-induced neurotoxicity. In: Toxicology of Metals (Chang L.W., ed.), Lewis Publishers, Boca Raton, pp. 561, 1996.
• 22. MAGNUSSON O., NILSON L.B., WESTERLAND D. Simultaneous determination of dopamine, DOPAC and homovanilic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography - electro­chemical detection system. J. Chromatogr. 221, 237, 1980.
• 23. CARLSSON A., DAVIS J.N., KEHR W., LINDQVIST M., ATACK C.V. Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Nau- nyn-Schmiedeberg's Arch. Pharmacol. 275, 153, 1972.
• 24. BRUS R., KOSTRZEWA R.M., PERRY K.W., FULLER R.W. Supersensitization of the oral response to SKF 38393 in neonatal 6-hydroxydopamine-lesioned rats is eliminated by neonatal 5,7-dihydroxytryptamine treatment. J. Pharma­col. Exper. Therap. 268, 231, 1994.
• 25. NAKAMURA K., THOENEN H. Increased irritability a permanent behaviour change induced in the rat by intracere- broventricular administration of 6-hydroxydopamine. Psychopharmacol. (Berlin) 24, 359, 1972.
• 26. RUMP S., KLEINROK Z. Pharmacometry, experimental meth­ods for the drugs studies. PZWL, Warsaw 1982 (in Polish).
• 27. KOSTRZEWA R.M., BRUS R. Ontogenic homologous supersensitization of quinpirole-induced yawning in rats. Pharmacol. Biochem. Behav. 39, 517, 1991.
• 28. DAMSMA G., BOTTEMA T., WESTERINK B.H.C., TEP­PER P.G., DIJKSTRA D., PUGSLEY T.A., MACKENZIE R., HEFFENR T.G. Pharmacologic aspects of R(+)OH- DPAT, a putative dopamine D3 receptor ligand. Eur. J. Phar­macol. 249, R9, 1993.
• 29. CREESE I., IVERSEN S.D. Behavioral sequel of dopami­nergic degeneration. In: Modern Pharmacology - Toxicol­ogy (Ellsodin J.R., Bunney J.R., eds.), Marcel Dekker Publ. 3, 171, 1975.
• 30. KOSTRZEWA R.M., KASTIN A.J. Tyramine-MIF1 attenu­ates development of tolerance to spiperone-induced cata­lepsy in rats. Brain Res. Bull. 31, 707, 1993.
• 31. BRUS R., SZKILNIK R., NOWAK P., KONECKI J., GŁOWACKA M., KASPERSKA A., OŚWIĘCIMSKA J., SAWCZUK K., SHANI J. Prenatal exposure of rats to lead induces changes in the reactivity of the central dopaminergic, serotoninergic and muscarinic receptors, but not in glucose up­take in their offspring. Pharmacol. Rev. Comm. 9, 299, 1997.
• 32. KISZKA W., SZKILNIK R., BRUS R., NOWAK P., KONECKI J., DURCZOK A., MENGEL K., SHANI J. Prenatal exposure of rats to mercury induces changes in central dopaminergic activity and in glucose uptake by their offspring. Pharmacol. Rev. Comm. 12, 77, 2002.
• 33. NOWAK P., BRUS R., LABUS Ł., SOKOŁA A., SHANI J. Modification of ontogenic neurochemical effects of cad­mium by ethanol in rats. Pharmacol. Rev. Comm. 12, 1, 2002.
• 34. RIORDAN J.F. Biochemistry of zinc. Med. Clin. North Am. 60, 661, 1976.
• 35. TAKEDA A. Movement of zinc and its functional signifi­cance in the brain. Brain Res., Brain Res. Rev., 34, 137, 2000.
• 36. KONECKI J., BIELACZYC G., NOWAK P., SZKILNIK R., SZCZERB AK G., SWOBODA M., KWIECIŃSKI A., KOSTRZEWA R.M., BRUS R. Effect of pre- and postna­tal exposure to zinc on (3H)glucose uptake in the brain and peripheral tissues of adult rats. Pol. J. Environ. Stud. 2005 (accepted).
• 37. SCHWARTZ J.C., GIROS B., MARTRES M.P., SOKOL- OFF P. Multiple dopamine receptors as molecular targets for antipsychotics. In: New Generation of Antipsychotic Drugs: Novel Mechanisms of Action (Brunello N., Man- dlewicz J., Racagui G., eds.), Int. Acad. Biomed. Drug Res. 4, 1, 1993.
• 38. KOSTRZEWA R.M., GONG I. Supersensitized Dj attenu­ates development of tolerance to spiperone-induced cata­lepsy in rats. Brain Res. Bull. 31, 707, 1991.
• 39. KOSTRZEWA R.M., BRUS R. Is dopamine-agonist-in- duced yawning behavior a D3 mediated event? Life Sci. 48, PL-129, 1991.
• 40. SANDSTEAD H.H. Zinc in human nutrition. In: Disorders of Mineral Metabolism (Bronner F., Coburn J.W., eds.), Ac­ademic Press, pp. 94-159, 1981.
• 41. GOERING P.L., KLAASSEN C.D. Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol. Appl. Pharmacol. 74, 299, 1984.
• 42. BLUMENTHAL S., LEWAND D., SOCHANIK A., KREZOSKI S., PETERING D.H. Inhibition of Na+-glucose cotransport in kidney cortical cells by cadmium and cop­per: protection by zinc. Toxicol. Appl. Pharmacol. 129, 177, 1994.
• 43. DURCZOK A., SZKILNIK R., NOWAK P., LABUS Ł., DĄBROWSKA J., BORTEL A., ZAGZIŁ T., SWOBODA M., RYCERSKI W., WINNICKA H., KOSTRZEWA R.M., BRUS R. Effect of zinc on the central dopaminergic system of rats prenatally exposed to cadmium. Pol. J. Environm. Stud. 14, 569, 2005.