Glutathione reductase activity correlates with concentration of extracellular matrix degradation products in synovial fluid from patients with joint diseases

• Autorzy: Sredzinska K. , Galicka A. , Porowska H. , Sredzinski L. , Porowski T. , Popko J.
• Języki publikacji: EN

Abstrakty

EN

 The mechanisms underlying cartilage matrix degradation in joint diseases is not fully understood but reactive oxygen species are implicated as main causative factors. Comparative studies of glutathione reductase (GR) activity in synovial fluid from patients with rheumatoid arthritis (RA), reactive arthritis (ReA) and osteoarthritis (OA) as well as correlations between GR activity and concentration of the major cartilage components in synovial fluid are presented in this study. We found significantly higher activity of GR in RA (about three-fold) and ReA (about two-fold) than in OA. In RA and ReA patients, GR activity in synovial fluid correlates negatively with the concentrations of collagen and degradation products of sulfated glycosaminoglycans. In OA patients the activity of GR was significantly lower than in RA and ReA, which positively correlated with the concentration of collagen and showed a tendency for positive correlation with the degradation products of sulfated glycosaminoglycans. Our results suggest that in RA and ReA patients increased activity of GR does not prevent the increased degradation of collagen and proteoglycans by ROS.

Słowa kluczowe

EN

joint disease; glutathione reductase activity; synovial fluid; human disease; reactive arthritis; extracellular matrix degradation product; glycosaminoglycan; osteoarthritis; pathogenesis; collagen; rheumatoid arthritis; patient; collagen degradation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2009
• Tom: 56
• Numer: 4
• Opis fizyczny: p.635-640,fig.,ref.

Twórcy

autor

Sredzinska K.

• Medical University of Bialystok, A.Mickiewicza 2a, 15-222 Bialystok, Poland

autor

Galicka A.

autor

Porowska H.

autor

Sredzinski L.

autor

Porowski T.

autor

Popko J.

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