Expression of cellular isoform of prion protein on the surface of peripheral blood lymphocytes among women exposed to low doses of ionizing radiation

• Autorzy: Klucinski P. , Mazur B. , Hrycek A. , Masluch E. , Cieslik P. , Kaufman J. , Martirosian G.
• Języki publikacji: EN

Abstrakty

EN

Ionizing radiation affects the expression of adhesive and co-stimulatory molecules in lymphocytes. The physiological function of cellular isoform of prion protein (PrPc) is little known. Evidences indicate a link between lymphocytes activation and PrPc expression on their surface; however, no direct effect of radiation on PrPc level in these cells was investigated. The objective of this study was to determinate the effect of low doses of ionizing radiation on the expression of PrPc on the surface peripheral blood lymphocytes in the women operating X-ray equipment. In 36 female workers and 30 persons of the control group the PrPc expression on CD3 (T lymphocytes), CD4 (T helper), CD8 (T cytotoxic) and CD19 (B lymphocytes), as well as the percentage of lymphocytes with PrPc on their surface, were tested. Subgroups with respect to age and length of employment were selected. A signifi cant increase was observed in PrPc expression on CD3 and CD4 with lowered PrPc level on CD8 and percentage of CD8 cells with PrPc in workers compared to control. The PrPc level did not show signifi cant changes in subgroups in relation to age (below and over 40 years old) both in the investigated and control groups, whereas a lower percentage of PrPc expressing CD19 cells showed in employed women below 40 years of age. A signifi cant decrease was found in PrPc expression on the surface of CD3, CD4 and CD8 cells in the subgroup employed for over 10 years than in the subgroup with less than 10 years of employment.

Słowa kluczowe

EN

blood lymphocyte; ionizing radiation; low dose; lymphocyte; cellular isoform; woman; radiation exposure; expression; prion protein

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2007
• Tom: 14
• Numer: 2
• Opis fizyczny: p.225-228,ref.

Twórcy

autor

Klucinski P.

• Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland

autor

Mazur B.

autor

Hrycek A.

autor

Masluch E.

autor

Cieslik P.

autor

Kaufman J.

autor

Martirosian G.

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