Effects of a bradycardic agent on postischemic cardiac recovery in rabbits

• Autorzy: Schmitz-Spanke S. , Granetzny A. , Stoffels B. , Pomblum V.J. , Gams E. , Schipke J.D.
• Języki publikacji: EN

Abstrakty

EN

Decreasing heart rate might be beneficial for improvement of myocardial energetics and could reduce the severity of myocardial ischemia. We examined the contribution of heart rate reduction by cilobradine (DK-AH 269), a direct sinus node inhibitor, on left ventricular function and peripheral vasomotion in anesthetized rabbits with experimental myocardial infarction. The rabbits were randomized to receive either placebo (n=10) or cilobradine (n=7). Cilobradine decreased significantly heart rate from 163 ± 33 to 131 ± 13 bpm, p< 0.05, without any inotopic or vascular effects. After 60 min coronary occlusion and 30 min reperfusion, both systolic and diastolic ventricular function were more reduced in the cilobradine group; i.e. maximal left ventricular pressure significantly decreased to 62 ± 11 mmHg, p < 0.05 (placebo: 77 ± 9 mmHg); dP/dtmin significantly decreased to -904 ± 247 mmHg, p < 0.05 (placebo: -1106 ± 242 mmHg). However, infarct size in the cilobradine group was significantly smaller compared with the placebo group. In conclusion, cilobradine reduced heart rate without any negative inotropic effect and reduced infarct size. On that account, this bradycardic agent might open a promising therapeutical avenue to treat postischemic dysfunction.

Słowa kluczowe

EN

myocardial infarction; verapamil; rabbit; left ventricular function; cilobradine; bradycardia; heart rate; myocardial ischaemia

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 4
• Opis fizyczny: p.705-712,fig.,ref.

Twórcy

autor

Schmitz-Spanke S.

• Universitatsklinikum Dusseldorf, Moorenstr.5, 40225 Dusseldorf, Germany

autor

Granetzny A.

autor

Stoffels B.

autor

Pomblum V.J.

autor

Gams E.

autor

Schipke J.D.