TP53 and mutations in human cancer

• Autorzy: Szymanska K. , Hainaut P.
• Języki publikacji: EN

Abstrakty

EN

TP53 is the most frequently mutated gene in human cancer, with a predominance of missense mutations scattered over 200 codons. In many cancers, specific mutation patterns can be identified, which are shaped by site-specific mutagenesis and by bio­logical selection. In tobacco-related cancers (lung, head and neck), organ-specific pat­terns are observed, with many mutations compatible with the ones experimentally in­duced by tobacco carcinogens. In several other cancers, such as squamous cell carci­noma of the oesophagus or hepatocellular carcinoma (HCC), mutation patterns show geographic variations between regions of high and low incidence, suggesting a role for region-specific risk factors. HCC from high-incidence regions showing also a high prevalence of a specific Ser-249 TP53 mutation is one of the most striking examples of a mutagen fingerprint. All such assessments are useful to generate clues on the mutagenic mechanisms involved in human cancer. Moreover, it has been shown that DNA retrieved from plasma can be successfully used for detection of TP53 mutations, which gives hope for earlier more accurate detection of human cancers.

Słowa kluczowe

EN

TP53 gene; man; mutation; cancer; human cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2003
• Tom: 50
• Numer: 1
• Opis fizyczny: p.231-238,fig.

Twórcy

autor

Szymanska K.

• International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon cedex 08, France

autor

Hainaut P.

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