The influence of modification at position 2 on the side-chain conformation in oxytocin analogs

• Autorzy: Smiech B. , Kazmierkiewicz R. , Lammek B.
• Języki publikacji: EN

Abstrakty

EN

The nonapeptide oxytocin (OT) is used in medicine to help begin and/or continue childbirth. Its analogs can be also used to control bleeding following fetus delivery. The main function of oxytocin is to stimulate contraction of uterus smooth muscle and the smooth muscle of mammary glands, thus regulating lactation. This paper describes theoretical simulations of the distribution of the torsional angles χ1 in the non-standard methylated phenylalanine residues of three oxytocin analogs: [(Phe)2o-Me]OT, [(Phe)2m-Me]OT, [(Phe)2p-Me]OT. The conformations of the oxytocin analogs were studied both in vacuum and in solution. We found some correlations between the biological activity of the considered peptides and the side-chain conformations of amino-acid residues 2 and 8.

Słowa kluczowe

EN

electrostatic driven Monte Carlo; oxytocin analogue; neonatal mortality; torsional angle distribution

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2006
• Tom: 53
• Numer: 1
• Opis fizyczny: p.113-120,fig.,ref.

Twórcy

autor

Smiech B.

• University of Gdansk, Gdansk, Poland

autor

Kazmierkiewicz R.

autor

Lammek B.

Bibliografia

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