Filogenetyczne pokrewienstwo ulicznych szczepow wirusa wscieklizny a reaktywnosc ich antygenow z przeciwcialami indukowanymi szczepem szczepionkowym. II. Zaleznosc pomiedzy dystansem genetycznym a reaktywnoscia przeciwcial

• Autorzy: Sadkowska-Todys M.
• Języki publikacji: PL

Abstrakty

PL

W przeprowadzonych badaniach wykazano, że stopień pokrewieństwa genetycznego szczepów wirusa wścieklizny ze szczepem szczepionkowym PM ma swoje odbicie w sile reaktywności przeciwciał nim indukowanych z białkami szczepów reprezentujących różne genotypy i warianty wirusa wścieklizny. Potwierdzono także, że wyniki testu ochrony czynnej z zastosowaniem szczepu CVS nie są w pełni obiektywnym miernikiem skuteczności szczepień ze względu na bliższe pokrewieństwo szczepu CVS ze szczepami szczepionkowymi niż z krążącymi w środowisku szczepami ulicznymi.

EN

The aim of these studies was the estimation of the influence of genetic divergence of reactivity with sera of people vaccinated against rabies of Polish rabies strains. Genetic similarity between CVS strain and street rabies strains of genotype 1 is relatively high. However, CVS strain showed the highest reactivity with standard immunoglobulin and sera of antirabies vaccinated people (measured by western blot method). It was completely different from street viruses. Cluster method based on genetic and serologic features indicated high difference between CVS strain and street rabies strains belonging to genotype 1 and genotype 5. On this basis CVS strain was classified as a separate cluster. The genetic divergence of rabies strains circulating in Poland suggests the need of permanent epidemiological and virological surveillance. Strains different in their genotypic and biotypic characteristics should be estimated according to their antigenic similarity to vaccine strain. In practice neutralisation test using mono- and policlonal sera should be performed. Strains isolated from new or atypical animal species should be studied first of all.

Słowa kluczowe

PL

pokrewienstwo filogenetyczne; wirus wscieklizny; zroznicowanie genetyczne; genotyp; szczepy uliczne; Polska; wscieklizna; szczepy laboratoryjne; przeciwciala; wirusy; szczepy wirusowe; dystans genetyczny; szczepy szczepionkowe; reaktywnosc

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2000
• Tom: 52
• Numer: 2
• Opis fizyczny: s.185-196,rys.,tab.,bibliogr.

Twórcy

autor

Sadkowska-Todys M.

• Panstwowy Zaklad Higieny, 00-791 Warszawa, ul.Chocimska 24

Bibliografia

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