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2003 | 08 | 1 |

Tytuł artykułu

A morphological and immunohistochemical investigation of guinea pig skin after the introduction of substance P and VIP

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to examine a morphological picture of guinea pig skin that had been injected with neuropeptides (NPS)2 - substance P (SP) and guinea pig vasoactive intestinal peptide (VIP) - to elucidate their local influence. Routine histological stainings were performed, together with immunohistochemical reactions for T cells and for macrophages. In the deeper layers of the skin, T cell and macrophagic infiltrations were observed. The intensity of these changes was greater 24 hours after injections than that observed at the third hour of the experiment.

Wydawca

-

Rocznik

Tom

08

Numer

1

Opis fizyczny

p.63-67,fig.

Twórcy

  • Medical University of Lodz, Narutowicza 60, 90-136 Lodz, Poland
autor
autor

Bibliografia

  • 1.Karanth, S.S., Springall, D.R., Kuhn, D.M., Levene, M.M. and Polak J.M. An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides in man and commonly employed laboratory animals. Am. J. Anat. 2191 (1991) 369-383.
  • 2.Pincelli, C., Fantini, F. and Giannetti, A. Neuropeptides and skin inflammation. Dermatology 187 (1993) 153-158.
  • 3.Didier, A., Kowalski, M.L., Jay, J. and Kaliner, M.A. Neurogenic inflammation, vascular permeability, and mast cells. Am. Rev. Respir. Dis. 41 (1990) 398-406.
  • 4.Payan, D.G. and Goetzl, E.J. Neuropeptide regulation of immediate and delayed hypersensitivity. Int. J. Neurosci. 38 (1988) 211-221.
  • 5.Kincy-Cain, T. and Bost, K.L. Substance P-induced IL-12 production by murine macrophages. J. Immunol. 158 (1997) 2334-2339.
  • 6.Schratzberger, P., Reinisch, N., Prodinger, W.M., Kahler, Ch.M., Sitte, B.A., Bellmann, R., Fischer-Colbrie, R., Winkler, H. and Wiedemann, Ch.J. Differential chemotactic activities of sensory neuropeptides for human peripheral blood mononuclear cells. J. Immunol. 158 (1997) 3895-3901.
  • 7.Danek, A., O’Dorisio, M.S., O’Dorisio, T.M. and George, J.M. Specific binding sites for vasoactive intestinal polypeptide on nonadherent peripheral blood lymphocytes. J. Immunol. 131 (1983) 1173-1177.
  • 8.Ottaway, C.A. and Greenberg, G.R. Interaction of VIP with mouse lymphocytes; specific binding and the modulation of mitogen responses. J. Immunol. 132 (1984) 417-423.
  • 9.Weidner, C., Klede, M., Rukwied, R., Lischetzki, G., Neisius, U., Skov, P.S., Petersen, L.J. and Schmeltz, M. Acute effects of substance P and calcitonin gene-related peptide in human skin - a microdialysis study. J. Innvest. Dermatol. 115 (2000) 1015-1020.
  • 10.Chan, J., Smoller, B.R., Raychauduri, S.P., Jiang, W. and Farber E.M. Intraepidermal nerve fiber expression of CGRP, VIP and substance P in psoriasis. Arch. Dermatol. Res. 289 (1997) 611-616.
  • 11.Misery, L. Skin, immunity and the nervous system. Br. J. Dermatol. 137 (1997) 843-850.
  • 12.Walsh, D.A., Wharton, J., Blake, D.R. and Polak, J.M. Neural and endothelial regulatory peptides, their possible involvement in inflammation. Int. J. Tiss. React. 14 (1992) 101-111.
  • 13.Gomariz, R.P., Martinez, C., Abad, C., Leceta, J. and Delgado, M. Immunology of VIP: a review and therapeutical perspectives. Curr. Pharm. Des. 7 (2001) 89-111.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-152c119e-2941-406d-92d1-7183459db61d
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