Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination

• Autorzy: Ciarkowski J. , Drabik P. , Gieldon A. , Kazmierkiewicz R. , Slusarz R.
• Języki publikacji: EN

Abstrakty

EN

G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate ac­tions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (in­active) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR mod­els are evaluated against the new experimental template. Subsequently, a working hy­pothesis regarding the signal transduction mechanism by GPCRs is presented.

Słowa kluczowe

EN

neurohypophyseal receptor; molecular modelling; G protein; coupled receptor; cell; signal transduction; rhodopsin structure; signal transmission; dark rhodopsin; light; G protein-coupled receptor; molecular dynamics

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1203-1207,fig.

Twórcy

autor

Ciarkowski J.

• University of Gdansk, J.Sobieskiego 18, 80-952 Gdansk, Poland

autor

Drabik P.

autor

Gieldon A.

autor

Kazmierkiewicz R.

autor

Slusarz R.

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