Thromboxane increase in irradiated animals is caused by stimulation of cyclooxygenase activity

• Autorzy: Sochanowicz B. , Dancewicz A.M.
• Języki publikacji: EN

Abstrakty

EN

The irradiation of whole body of rabbits with a dose <»l' 6.0 Gy causes an increase in thromboxane synthesis from exogenous arachidonic acid. The uptake of |l4C]arachidonic acid and the total amount of radioac- tivity released during collagen stimulated aggregation of platelets are not changed following the exposure of animals. The irradiation changes the relation between released arachidonic acid and synthesized throm­boxane. 1'he amount of 12-hydroxyeicosatetraenoic acid remains un­changed. The results indicate that the increase in thromboxane synthesis is not associated with the activation of phospholipase but is caused by stimulation of cyclooxygenase activity.

Słowa kluczowe

EN

cyclooxygenase activity; irradiation; thromboxane; animal

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1992
• Tom: 39
• Numer: 3
• Opis fizyczny: p.271-281,fig.

Twórcy

autor

Sochanowicz B.

• Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland

autor

Dancewicz A.M.

Bibliografia

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