Lead, cadmium, copper and zine concentrations in blood and hair of mothers of children with locomotor system malformations

• Autorzy: Popko J , Olszewski S. , Hukalowicz K. , Markiewicz R. , Borawska M.H. , Szeparowicz P.
• Języki publikacji: EN

Abstrakty

EN

Cadmium, copper and zinc concentrations in the blood and hair of 51 women after delivery of children with locomotor system malformations (Group I) and, as a control, 46 women who gave birth to healthy children (Group II) were different but none of the values were statistically significant. However, lead concentrations in the blood and the hair of women from the Group I (median: 109.63 μg/L and 1.31 μg/g) were notably higher than in Group II (median: 66.45 μg/L and 0.58 μg/g, respectively). Maternal lead concentrations in the blood of 17 women from Group I decreased to 60.73 μg/L, and in their hair to 1.20 μg/g after 12 months. We observed a significant correlation between lead concentrations and copper levels in the hair of the mothers.

Słowa kluczowe

EN

hair; metal; locomotor system malformation; concentration; blood; cadmium; child; zinc; copper; lead

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2003
• Tom: 12
• Numer: 3
• Opis fizyczny: p.375-379

Twórcy

autor

Popko J

• Medical University in Bialystok, J.Waszyngtona 17, 15-274 Bialystok, Poland

autor

Olszewski S.

autor

Hukalowicz K.

autor

Markiewicz R.

autor

Borawska M.H.

autor

Szeparowicz P.

Bibliografia

• 1. UZYCH L. Teratogenesis and mutagenesis associated with the exposure of human males to lead: a review. Yale J. Biol. Med. 58, 9, 1985.
• 2. GRANT L. D., DAVIS J. M. Effects of low level lead exposure on paediatric neurobehavioural development: current findings and future directions. Kluwer Academic Publishers, Dordrecht 1989.
• 3. MACDONELL J.E., CAMPBELL H., STONE D. H. Lead levels in domestic water supplies and neural tube defects in Glasgow. Arch. Dis. Child. 82, 50, 2000.
• 4. SALLMEN M., LINDBOHM M. L., ANTILLA A. TASKINEN H., HEMMINKI K. Paternal occupational lead exposure and congenital malformations. J. Epidemiol. Community Health. 46, 519, 1992.
• 5. DUDEK B. Toxic effects of lead in children. Med. Pr. 44, (6 suppl.1), 101, 1993.
• 6. MICHALIK T., ANDRZEJAK R. Stężenie metali ciężkich (Pb, Cd) w pełnej krwi u ciężarnych zagrożonych wystąpieniem porodu przedwczesnego. Gin. Pol. 68, (suppl. 5b), 59, 1997.
• 7. FANG M.Z., MAR W., CHO M.H. Cadmium affects genes involved in growth regulation during two – stage transformation of Balb/3T3 cells. Toxicology 15, 253, 2002.
• 8. HURLEY L.S., SWENERTON H. Congenital malformations resulting from zinc deficiency in rats. Proc. Soc. Exp. Biol. Med. 123, 692, 1966.
• 9. DREOSTI T.E. Zinc in prenatal development. In: Clinical applications of recent advances in zinc metabolism. Ed.: Alan R. Liss: New York, pp. 19-38, 1982
• 10. KRACHLER M., ROSSIPAL E., MICETIC – TURK D. Trace element transfer from the mother to the newborn – investigations on triplets of colostrum, maternal and umbilical cord sera. Eur. J. Clin. Nutr. 53, 487, 1999.
• 11. UAUY R., OLIVARES M., GONZALEZ M. Essentiality of copper in humans. Am.J.Clin. Nutr. (suppl.) 67, 952s, 1998.
• 12. JAKUBOWSKI J., KABATA J., KALINOWSKI L., SZCZEPAŃSKA – KONKEL M., ANGIELSKI S. Badania laboratoryjne w codziennej praktyce. MAKmed., Gdańsk, 1996.
• 13. KANIEWSKI A., TAKAGI Y., MARCINKOWSKI JT. Concentrations of 21 elements in hair of people living in Poznań. Probl. Med. Społ. 32, 391, 1997.
• 14. JAKUBOWSKI M. Biological levels of cadmium in residents of Poland. Med. Pr. 46, (suppl. 5), 83, 1995.
• 15. NEUMEISTER B., BESENTHAL J., LIEBICH H. Diagnostyka laboratoryjna. Urban and Partner, Wrocław, 2001.
• 16. RADOMSKA K., GRACZYK A., KONARSKI J., ADAMOWICZ B. Evaluation of macro- and micro-element content in the human body determined by hair analysis. Pol. Tyg. Lek. 46, 24, 1991.
• 17. STOLL C., DOTT B., ALEMBIC Y., KOEHL C. Maternal trace elements, vitamin B12, vitamin A, folic acid, and fetal malformations. Reprod. Toxicol. 13, 53, 1999.
• 18. SCHRAMEL P., LILL G., HASSE S., KLOSE B.J. b Mineral- and trace element concentrations in human breast milk, placenta, maternal blood, and the blood of the newborn. Biol. Trace Elem. Res. 16, 67, 1988.
• 19. DURSKA G., KOZIELEC T., KARAKIEWICZ B. Ocena gradientu przezłożyskowego dla ołowiu i kadmu. Gin. Pol. 73, 43, 2002.
• 20. BORAWSKA M.H., POPKO J., OLSZEWSKI S., HUKAŁOWICZ K., MARKIEWICZ R. Lead contents in mothers and newborns with locomotor system malformations. Metal Ions in Biology and Medicine. Ed.: L. Khassanova, P. Collery, I. Maymard, Z. Khassanova, J.C. Etienne, John Libbey Eurotext, 7, 437 Paris 2002.
• 21. LAGERKVIST B. J., EKESRYDH S., ENGLYST V., NORDBERG G. F., SODERBERG H. A., WIKLUND D. E. Increased blood lead and decreased calcium levels during pregnancy: a prospective study of Swedish women living near a smelter. Am. J. Public. Health. 86, 1247, 1996.
• 22. MARKOWITZ M. E., SHEN X. M. Assesment of bone lead during pregnancy: a pilot study. Environ Res. 85, 83, 2001.
• 23. SAXENA D.K., SINGH C., MURTHY R.C., MATHUR N., CHANDRA S.V. Blood and placental lead levels in an Indian city: a preliminary report. Arch. Environ. Health. 49, 106, 1994.
• 24. ZARĘBA A., STRUGAŁA-STAWIK H., RUDKOWSKI Z., DEMBICKA D., PASTUSZEK B., JĘDRZEJCZUK-MUSIAK A. Blood lead levels in mothers and their neonates – ecological factors and influence on fetus growth. Ped. Pol. 71, (4 suppl.) 87, 1996.