5',8-cyclo-2'-deoxyadenosine [cdA] formation by gamma-radiation. Theoretical quantum mechanics study

• Autorzy: Karwowski B. T. , Grand A. , Cadet J.
• Języki publikacji: EN

Abstrakty

EN

 Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties. In the present study emphasis was put on the possible reaction modes of 2'-deoxyadenosine (dA) radicals, leading to the formation of related 5',8-cyclonucleosides. It appears that the prerequisite for the formation of 5',8-cyclo-2'-deoxyadenosine (cdA) is the adoption of O4'-exo conformation by 2-deoxyribose; however, this is the least energetically favored conformer among the different puckered forms adopted by the furanose ring. The O4'-exo conformation was found to be present in each of the discussed mechanisms.

Słowa kluczowe

EN

quantum mechanics; density functional theory; reactive oxygen species; mechanism; 5',8-cyclo-2'-deoxyadenosine; ionizing radiation; DNA damage

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2009
• Tom: 56
• Numer: 4
• Opis fizyczny: p.655-662,fig.,ref.

Twórcy

autor

Karwowski B. T.

• Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland

autor

Grand A.

autor

Cadet J.

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