Elevation of plasma fibrinogen in silent myocardial ischaemia

• Autorzy: Grzywacz A. , Psuja P. , Zozulinska M. , Elikowski W. , Zawilska K.
• Języki publikacji: EN

Abstrakty

EN

High plasma levels of fibrinogen and plasminogen activator inhibitor (PAI-1) are reported to be correlated with coronary heart disease. Therefore the level of fibrinogen concentration in plasma was examined and verified for the possible correlation with the previously explored PAI-1 antigen and PAI-1 activity in the pathogenesis of premature atherosclerosis (Grzywaczet al., 1998,Blood Coagul Fibrinol. 9, 245-249). Examination included only men, aged 33-46 years, who were in a stable condition for at least six months after the acute event. They were divided into two subgroups: group A (n = 14) with and group B (n = 15) without ischaemic changes in 24 h Holter electrocardiogram. The number of involved vessels visible on the coronarography picture was similar in both groups. In the patients of group A the mean level of fibrinogen (3.92 vs 3.23 g/l, P < 0.05) was higher than in the controls (n = 15). No statistically differences were found between group B and control healthy subjects in any of the parameters measured. There were no correlation between fibrinogen concentration and PAI-1 antigen and activity levels, which were elevated in both groups of patients according to our previous study. Our results indicate that elevated levels of plasma fibrinogen and PAI-1 appeared in the group of patients with more severe disease, as revealed by silent myocardial ischaemia.

Słowa kluczowe

EN

tobacco smoking; silent myocardial ischaemia; cardiovascular risk factor; plasminogen; heart disease; diabetes mellitus; fibrinogen; hyperlipidemia; arterial hypertension; obesity

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 4
• Opis fizyczny: p.985-989

Twórcy

autor

Grzywacz A.

• K.Marcinkowski University of Medical Sciences, Szkolna 8-12, 60-833 Poznan, Poland

autor

Psuja P.

autor

Zozulinska M.

autor

Elikowski W.

autor

Zawilska K.

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