Communication between microorganisms as a basis for production of virulence factors

• Autorzy: Gospodarek E , Bogiel T. , Zalas-Wiecek P.
• Języki publikacji: EN

Abstrakty

EN

Quorum sensing (QS), or cell-to-cell communication in bacteria, is achieved through the production and subsequent response to the accumulation of extracellular signal molecules called autoinductors. The main role of QS is regulation of production of virulence factors in bacteria. Bacterial pathogenicity is often manifested by the expression of various cell-associated and secreted virulence factors, such as exoenzymes, toxins and biofilm. In bacteria, the expression of virulence factors is controlled coordinately by the global regulatory QS systems, which includes the AI-1/LuxIR-, AI-2/LuxS-, AI-3/QsC-, AIP/Agr-based systems. The regulation of production of virulence factors is extremely complex and many components influence it.

Słowa kluczowe

EN

toxin; extracellular signal; bacteria; virulence factor; pathogenesis; quorum sensing; biofilm; autoinductor; microorganism; communication

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2009
• Tom: 58
• Numer: 3
• Opis fizyczny: p.191-198,ref.

Twórcy

autor

Gospodarek E

• Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, 9 M.Sklodowska-Curie St., 85-094 Bydgoszcz, Poland

autor

Bogiel T.

autor

Zalas-Wiecek P.

Bibliografia

• Ahmer B.M., J. van Reeuwijk, C.D. Timmers, P.J. Valentine and F. Heffron. 1998. Salmonella Typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid. J. Bacterial. 180: 1185-1193.
• Blevins J.S., M.O. Elasri, S.D. Allmendinger, K.E. Beenken, R.A. Skinner, J.R. Thomas and M.S. Smeltzer. 2003. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect. Immun. 71: 516-523.
• Clarke M.B., D.T. Hughes, C. Zhu, E.C. Boedeker and V. Sperandio. 2006. The QseC sensor kinase: a bacterial adrenergic receptor. Proc. Natl. Acad. Set. USA 103: 10420-10425.
• Coulthurst S.J., N.R. Williamson, A.K. Harris, D.R. Spring and G.P. Salmond. 2006. Metabolic and regulatory engineering of Serratia marcescens: mimicking phage mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities. Microbiology 152: 1899-1911.
• De Kievit T.R. and B.H. Iglewski. 2000. Bacterial quorum sensing in pathogenic relationships. Infect. Immun. 68: 4839-4849.
• Devine J.H., G.S. Shadel and T.O. Baldwin. 1989. Identification of the operator of the lux regulon from the Vibrio fischeri strain ATCC7744. Proc. Natl. Acad. Sci: USA 86: 5688-5692.
• Gillaspy A.F., S.G. Hickmon, R.A. Skinner, J.R. Thomas, C.L. Nelson and M.S. Smeltzer. 1995. Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect. Immun. 63: 3373-3380.
• Girand G. and G.V. Bloemberg. 2008. Central role of quorum sensing in regulating the production of pathogenicity factors in Pseudomonas aeruginosa. Future Microbiol. 3: 97-106.
• Haas W., B.D. Shepard and M.S. Gilmore. 2002. Two component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction. Nature 415: 84-87.
• Hammer B.K. and B.L. Bassler. 2009. Distinct sensory pathway in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation. J. Bacterial. 191: 169-177.
• Hoffman L.R., H.D. Kulasckara, J. Mcrson, L.S. Houston, J.L. Burns, B.W. Ramsey and S.I. Miller. 2009. Pseudomonas aeruginosa lasR mutant are associated with cystic fibrosis lung disease progression. J. Cyst. Fibros. 8: 66-70.
• Hsieh H.Y., Ch.W. Tseng and G.C. Stewart. 2008. Regulation of Rot expression in Staphylococcus aureus. J. Bacterial. 190: 546-554.
• Kanamaru K., K. Kanamaru, L Tatsuno, T. Tobe and C. Sasakawa. 2000. SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7. Mol. Microbiol. 38: 805-816.
• Li M., A.E. Villaruz, V. Vadyvaloo, D.E. Sturdevant and M. Otto. 2008. AI-2-dependent gene regulation in Staphylococcus epidermidis. BMC Microbiol. 8: 1-9.
• Liang H., L. Li, Z. Dong, M.G. Surette and K. Duan. 2008. The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J. Bacterial. 190: 6217-6227.
• Lyon G.J., P. Mayville, T.W. Muir and R.P. Novick. 2000. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proc. Natl. Acad. Sci. USA 97: 13330-13335.
• Michael B., J.N. Smith, S. Swift, F. Heffron and B.M. Ahmer. 2001. SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities. J. Bacterial. 183: 5733-5742.
• Nakamura S., Y. Higashiyama, K. Izumikawa, M. Seki, H. Kakeya, Y. Yamamoto, K. Yanagihara, Y. Miyazaki, Y. Mizuta and S. Kohno. 2008. The roles of the quorum sensing system in the release of extracellular DNA, lipopolisaccharide, and membrane vesicles from Pseudomonas aeruginosa. Jpn. J. Infect. Dis. 61: 375-378.
• Pacheco A.R. and V. Sperandio. 2009. Inter - kingdom signaling: chemical language between bacteria and host. Curr. Opinion Microbiol. 12: 192-198.
• Pearson J.P., M. Feldman, B.H. Iglewski and A. Prince. 2000. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immun. 68: 4331-4334.
• Qin X., K.V. Singh, G.M. Weinstock and B.E. Murray. 2000. Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence. Infect. Immun. 68: 2579-2586.
• Rumbaugh K.P., S.P. Diggle, Ch.M. Watters, A. Ross-Gillespie, A.S. Griffin and S.A. West. 2009. Quorum sensing and social evolution of bacterial virulence. Curr. Biol. 19, 341-345.
• Schaefer A.L., D.L. Val, B.L. Hanzelka, J.E. Cronan Jr and E.P. Greenberg. 1996. Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein. Proc. Natl. Acad. Sci. USA 93: 9505-9509.
• Schuster M. and Greenberg E.P. 2006. A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa. Int. J. Med. Microbiol. 296: 73-81.
• Shank E.A. and R. Kolter. 2009. New developments in microbial interspecies signaling. Curr. Opin. Microbiol. 12: 205-214.
• Sperandio V., J.L. Mellies, W. Nguyen, S. Shin and J.B. Kaper. 1999. Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 96: 15196-15201.
• Sperandio V., A.G. Torres, J.A. Giron and J.B. Kaper. 2001. Quorum sensing is a global regulatory mechanism in enterohemorrhagic Escherichia coli O157:H7. J. Bacterial. 183: 5187-5197.
• Sperandio V., C.C. Li and J.B. Kaper. 2002. Quorum sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli. Infect. Immun. 70: 3085-3093.
• Sperandio V., A.G. Torres, B. Jarvis, J.P. Nataro and J.B. Kaper. 2003. Bacteria-host communication: the language of hormones. Proc. Natl. Acad. Sci. USA 100: 8951-8956.
• Taga M.E., J.L. Semmelhack and B.L. Bassler. 2001. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol. Microbiol. 42: 777-793.
• Tateda K., Y. Ishii, M. Horikawa, T. Matsumoto, S. Miyairi, J.C. Pechere, T.J. Standiford, M. Ishiguro and K. Yamaguchi. 2003. The Pseudomonas aeruginosa autoinducer N-3-oxododeca-noyl homoserine lactone accelerates apoptosis in macrophages and neutrophils. Infect. Immun. 71: 5785-5793.
• Ueda A. and T.K. Wood. 2009. Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA. PLoS Pathog. 5: 1-15.
• Walters M., M.P. Sircili and V. Sperandio. 2006. AI-3 synthesis is not dependent on luxS in Escherichia coli. J. Bacterial. 188: 5668-5681.
• Williams P. and M. Cámara. 2009. Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules. Curr. Opin. Microbiol. 12: 182-191.
• Xavier K.B. and B.L. Bassler. 2003. LuxS quorum sensing: more than just a numbers game. Curr. Opin. Microbiol. 6: 191-197.
• Yao Y., C. Vuona, S. Kocianova, A.E. Villaruz, Y. Lai, D.E. Sturdevant and M. Otto. 2006. Characterization of the Staphylococcus epidermidis accessory-gene regulator response: quorum sensing regulation of resistance to human innate host defense. J.I.D. 93: 841-848.
• Zeng J., F. Teng and B.E. Murray. 2005. Gelatinase is important for translocation of Enterococcus faecalis across polarized human enterocyte-like T84 cells. Infect. Immun. 73: 1606-1612.
• Zhang K., M. Ou, W. Wang and J. Ling. 2009. Effects of quorum sensing on cell viability in Streptococcus mutans biofilm formation. Biochem. Biophys. Res. Communications. 379: 933-938.
• Zhu J., M.B. Miller, R.E. Vance, M. Dziejman, B.L. Bassler and J.J. Mekalanos. 2002. Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc. Natl. Acad. Sci. USA 99: 3129-3134.