Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease

• Autorzy: Zekanowski C , Wojda U.
• Języki publikacji: EN

Abstrakty

EN

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.

Słowa kluczowe

EN

neurodegenerative disease; human disease; Alzheimer's disease; cell cycle; aneuploidy; chromosome missegregation; Down's syndrome; genome instability; apoptosis; oxidative stress; DNA damage; DNA repair; neuron; presenilin

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 2
• Opis fizyczny: p.232-253,fig.,ref.

Twórcy

autor

Zekanowski C

• Polish Academy od Sciences, Warsaw, Poland

autor

Wojda U.

Bibliografia

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