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2008 | 64 | 04B |

Tytuł artykułu

Zwrotny i lokalnie docelowy transfer macicznej PGE2 w cyklu rujowym u swini

Warianty tytułu

EN
Retrograde and local destination transfer of uterine prostaglandin E2 during the porcine oestrous cycle

Języki publikacji

PL

Abstrakty

EN
The aim of the present study was to establish: a) whether PGE₂ can permeate from venous and lymphatic vessels of the mesometrium to arterial blood and be retrograde transferred to the uterine horn during the porcine oestrous cycle; and b) whether PGE₂ can reach the ovary and oviduct by local destination transfer. The experiments were performed on days 9-10 (middle luteal phase), 13-14 (initiation of luteolysis), 16-18 (follicular phase) of the oestrous cycle. [³H]PGE₂ at a total dose of 5.5 × 10⁷ d.p.m. (49 ng) was infused into the most superficial layer of the myometrium under the serosa. The results demonstrated the permeation of PGE₂ from venous blood, uterine lymph and mesometrial tissues into arterial blood and its retrograde transfer into the uterine horn. The efficiency of retrograde transfer of prostaglandin to the uterine horn was high in all phases of the oestrous cycle, excluding the period of luteolysis. The local destination transfer of PGE₂ from the uterus to the ovary and oviduct was also demonstrated. The efficiency of local destination transfer of PGE₂ to the ovary was the highest in the middle luteal phase. The authors conclude that retrograde and local destination transfer of PGE₂ may enable effective access of this hormone to target organs and reduce its outflow with venous blood.

Wydawca

-

Rocznik

Tom

64

Numer

04B

Opis fizyczny

s.588-591,rys.,bibliogr.

Twórcy

autor
  • Instytut Rozrodu Zwierzat i Badan Zywnosci PAN, ul.Tuwima 10, 10-747 Olsztyn
autor

Bibliografia

  • 1. Akinlosotu B. A., Diehl J. R., Gimenez T.: Sparing effect of uterine treatment with prostaglandin E₂ on luteal function in cycling gilts. Prostaglandins 1986, 32, 291-293.
  • 2. Arosh J. A., Banu S. K., Chapdelaine P., Madore E., Sirois J., Fortier M. A.: Prostaglandin biosynthesis, transport and signaling in corpus luteum: a basis for autoregulation of luteal function. Endocrinology 2004, 145, 2551-2560.
  • 3. Banu S. K., Arosh J. A., Chapdelaine P., Fortier M. A.: Molecular cloning and spatio-temporal expression of the prostaglandin transporter: a basis for the action of prostaglandins in the bovine reproductive system. Proc. Natl Acad. Sci. USA 2003, 100, 11747-11752.
  • 4. Bell L. A., Gimenez T., Diehl J. R., Chakraborty P. K.: Prostaglandin E₂ and progesterone during the estrous cycle of pig. Anim. Reprod. Sci. 1990, 22, 325-337.
  • 5. Blitek A., Wacławik A., Kaczmarek M. M., Stadejek T., Pejsak Z., Zięcik A. J.: Expression of cyclooxynase-1 and -2 in the porcine endometrium during the oestrous cycle and early pregnancy. Reprod. Domest. Anim. 2006, 41, 251-257.
  • 6. Cao J., Yosida M., Kitazawa T., Taneike T.: Uterine region-dependent differences in responsiveness to prostaglandins in the non-pregnant porcine myometrium. Prostaglandins Other Lipid Mediat. 2005, 75, 105-122.
  • 7. Chan B. S., Satriano J. A., Pucci M. L., Schuster V. L.: Mechanism of prostaglandin E₂ transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter PGT. J. Biol. Chem. 1998, 273, 6689-6697.
  • 8. Chłopek J.: Lokalny dojajnikowy i zwrotny domaciczny transfer prostaglandyny E₂ w cyklu rujowym i we wczesnej ciąży u świni. Praca doktorska, Wydział Medycyny Weterynaryjnej, Olsztyn 2007.
  • 9. Critchley H. O., Osei J., Henderson T. A., Boswell L., Sales K. J., Jabbour H. N., Hirani N.: Hypoxia-inducible factor-1á expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2). Endocrinology 2006, 147, 744-753.
  • 10. Duckworth N., Marshall K., Clayton J. K.: An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women. J. Endocrinol. 2002, 172, 263-269.
  • 11. Franczak A., Kurowicka B., Oponowicz A., Petroff B. K., Kotwica G.: The effect of progesterone on oxytocin-stimulated intracellular mobilization of Ca²⁺ and prostaglandin E₂ and F₂α secretion from porcine myometrial cells. Prostaglandins Other Lipid Mediat. 2006, 81, 37-44.
  • 12. Krzymowski T., Czarnocki J., Koziorowski M., Kotwica J., Stefańczyk-Krzymowska S.: Counter current transfer of ³H-PGF₂α in the mesometrium: a possible mechanism for prevention of luteal regression. Anim. Reprod. Sci. 1986, 11, 259-272.
  • 13. Krzymowski T., Stefańczyk-Krzymowska S.: The role of the endometrium in endocrine regulation of the animal oestrous cycle. Reprod. Dom. Anim. doi: 10.1111/j.1439-0531.2007.00859.x.
  • 14. Lyons C., Beharry K., Akmal Y., Attenello F., Nageotte M. P.: In vitro response of prostaglandin E₂ receptor (EP3) in the term pregnant rat uterus and cervix to misoprostol. Prostaglandins Other Lipid Mediat. 2003, 70, 317-329.
  • 15. McCracken J. A., Carlson J. C., Glew M. E., Goding J. R., Green K., Samuelsson N.: Prostaglandin F2α identified as a luteolytic hormone in sheep. Nature, New Biol. 1972, 238, 129-134.
  • 16. McCracken J. A., Custer E. E., Lamsa J. C.: Luteolysis: a neuroendocrinemediated event. Physiol. Rev. 1999, 79, 263-323.
  • 17. Orlicky D. L., Liberman L., Gerschenson L. E.: Prostaglandin F₂α and E₁ regulation in primary cultures of rabbit endometrial cells. J. Cell. Physiol. 1986, 127, 55-60.
  • 18. Rodriguez-Martinez H., Einarsson S.: Influence of prostaglandins on the spontaneous motility of pig oviducts. Anim. Reprod. Sci. 1985, 8, 259-279.
  • 19. Schuster V. L.: Prostaglandin transport. Prostaglandins Other Lipid Mediat. 2002, 68-69, 633-647.
  • 20. Stefańczyk-Krzymowska S.: Rola przeciwprądowego przenikania hormonów w regulacji czynności jajnika i macicy u świni. Acta Acad. Agric. Tech. Olst. 527, Zootech. Suppl. A, 1996, 45, 1-59.
  • 21. Stefańczyk-Krzymowska S., Chłopek J., Grzegorzewski W., Radomski M.: Local transfer of prostaglandin E₂ into the ovary and its retrograde transfer into the uterus in early pregnant sows. Exp. Physiol. 2005, 90, 807-814.
  • 22. Stefańczyk-Krzymowska S., Krzymowski T.: Docelowy i zwrotny transfer macicznych prostaglandyn F₂α i E₂ oraz jego znaczenie w regulacji czynności macicy, jajowodu i jajnika. Medycyna Wet. 2008 (oddano do druku).
  • 23. Stefańczyk-Krzymowska S., Krzymowski T., Einer-Jensen N., Kamiński T., Kotwica J.: Local transfer of prostaglandin F₂α from the uterine lumen into the venous and arterial blood and into the uterine, mesometrial and ovarian tissue on day 18 of pregnancy in the pig. Anim. Reprod. Sci. 1990, 23, 223-235.
  • 24. Stefańczyk-Krzymowska S., Wąsowska B., Chłopek J., Gilun P., Grzegorzewski W., Radomski M.: Retrograde and local destination transfer of uterine prostaglandin E₂ in early pregnant sow and its physiological consequences. Prostaglandins Other Lipid Mediat. 2006, 81, 71-79.
  • 25. Wacławik A., Rivero-Muller A., Blitek A., Kaczmarek M. M., Brokken L. J. S., Watanabe K., Rahman N. A., Zięcik A. J.: Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium. Endocrinology 2006, 147, 210-221.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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