Experimental toxoplasmosis of the central nervous system in rabbits as a model of human infection

• Autorzy: Dzbenski T H , Bitkowska E , Golab E , Waloch M
• Języki publikacji: EN

Abstrakty

EN

Rabbits were infected by intraventricular injection of tachyzoites of the RH strain of Toxoplasma gondii and examined for a laboratory evidence of toxoplasmosis at the advanced stage of infection. From the examined samples of cerebrospinal fluid (CSF), blood and brain sections, the samples of spinal fluid appeared frequently negative for toxoplasmosis in spite of very sensitive methods that had been used in the diagnostic procedure. Most probable explanation of the low efficiency of diagnostic methods based on examination of the spinal fluid was a slow circulation of the CSF, which did not promote dissemination of parasites within cerebral ventricles and subarachnoid spaces. The results of the studies allowed to conclude that rabbits infected by intraventricular injection of T. gondii provide a good model of toxoplasmosis of the central nervous system which may facilitate evaluation of the efficiency of diagnostic procedures used to differentiate the condition.

Słowa kluczowe

EN

human infection; infection; spinal fluid; Toxoplasma gondii; blood; central nervous system; protozoan parasite; intraventricular injection; cerebrospinal fluid; parasite; subarachnoid space; toxoplasmosis; cerebral ventricle; brain section; diagnostic method; rabbit

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1998
• Tom: 43
• Numer: 3
• Opis fizyczny: p.162-166,fig.

Twórcy

autor

Dzbenski T H

• Department of Medical Parasitology, National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland

autor

Bitkowska E

• Department of Medical Parasitology, National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland

autor

Golab E

• Department of Medical Parasitology, National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland

autor

Waloch M

• Department of Medical Parasitology, National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland

Bibliografia

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• Conley F. K., Jenkins K. A., Remington J. S. 1981. Toxoplasma gondii infection in the central nervous system. Use of the peroxidase-antiperoxidase method to demonstrate Toxoplasma in formalin fixed, paraffin embedded tissue sections. Human Pathology, 12, 690-698.
• Eggers C., Gross U., Klinker H., Schalke B., Stellbrink H. J., Kunze K. 1995. Limited value of cerebrospinal fluid for direct detection of Toxoplasma gondii in toxoplasmic encephalitis associated with AIDS. Journal of Neurology, 242, 644-649.