Preliminary pharmacological investigations of biotransformed roseroot [Rhodiola rosea L.] callus tissue

• Autorzy: Krajewska-Patan A , Dreger M. , Lowicka A. , Gorska-Paukszta M. , Mscisz A. , Mikolajczak P.L. , Buchwald W. , Furmanowa M. , Mrozikiewicz P.M.

Warianty tytułu

PL

Wstepne badania farmakologiczne biotransformowanych tkanek kalusowych rozenca gorskiego [Rhodiola rosea L.]

• Języki publikacji: EN

Abstrakty

EN

Callus tissues from Rhodiola rosea L., a plant popular in traditional Russian and Asian medicine, treated with biosynthesis precursors of salidroside (p-tyrosol) and rosavins (cinnamic alcohol), were tested on the animals for the pharmacological activities of the extracts. Authors investigated the behavioural activity using locomotor activity and the motor coordination test. A single administration of extract from the callus tissue non treated with precursors resulted in stimulant effects on rats. The extract enriched in rosavins (after biotransformation) showed the inhibition of activity of tested animals. The more detailed studies concerning the exact nature of the effects especially after chronic administration are needed.

PL

Badano tkanki kalusowe uzyskane in vitro z różeńca górskiego (Rhodiola rosea L.), rośliny tradycyjnie stosowanej w medycynie dalekowschodniej. Materiał roślinny poddawany był procesowi biotransformacji poprzez dodatek do pożywek wzrostowych prekursorów biosyntezy: p-tyrozolu (prekursora salidrozydu) i alkoholu cynamonowego (prekursora rozawin). Badano aktywność behawioralną ekstraktów otrzymanych z kalusa poddanego biotransformacji, stosując testy na szczurach na aktywność motoryczną i koordynację ruchową. Ekstrakt z kalusa nie poddanego biotransformacji po jednorazowym podaniu działał stymulująco w zastosowanych testach, natomiast wyciąg z kalusa o zawartości rozawin zwiększonej po biotransformacji działał hamująco na aktywność badanych zwierząt. Konieczne są dalsze badania wyjaśniające działanie wyciągów z tkanek kalusowych R. rosea, szczególnie po długotrwałym podawaniu.

Słowa kluczowe

EN

biotransformation; salidroside; roseroot; callus tissue; cinnamyl alcohol; callus culture; pharmacological investigation; rosavin; biotransformed tissue; Rhodiola rosea

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2008
• Tom: 54
• Numer: 3
• Opis fizyczny: p.50-58,ref.

Twórcy

autor

Krajewska-Patan A

• Research Institute of Medicinal Plant, Libelta 27, 61-707 Poznan, Poland

autor

Dreger M.

autor

Lowicka A.

autor

Gorska-Paukszta M.

autor

Mscisz A.

autor

Mikolajczak P.L.

autor

Buchwald W.

autor

Furmanowa M.

autor

Mrozikiewicz P.M.

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