Wrazliwosc na antybiotyki z grupy makrolidow paleczek Bordetella pertussis i Bordetella parapertussis wyizolowanych od chorych na krztusiec w 1968 roku i w latach 1997-99

• Autorzy: Chodorowska M. , Kuklinska D. , Tyski S.
• Języki publikacji: PL

Abstrakty

PL

Określono wrażliwość na antybiotyki makrolidowe szczepów B. pertussis i B. parapertussis izolowanych od chorych dzieci w latach 1968 i 1997-99. Nie stwierdzono znaczących różnic we wrażliwości na te antybiotyki badanych szczepów. Najbardziej aktywnym antybiotykiem wobec wszystkich szczepów okazała się azytromycyna, a najmniejszą aktywność wykazała spiramycyna i oleandomycyna.

EN

The activity of erythromycin, azithromycin, clarithromycin, dirithromycin, oleandomycin, roxithromycin, spiramycin and josamycin against 21 and 34 B. pertussis strains and against 6 and 8 B. parapertussis strains isolated respectively in the years 1968 and 1997—99 was examined. The antibiotic agar dilution method was used. The minimum concentration of macrolides which inhibited growth of B. pertussis and B. parapertussis was calculated for 50% (MIC50) and 90% (MIC90) of isolates. The susceptibility to macrolides of B. pertussis and B. parapertussis strains isolated in the years 1968 and 1997-99 did not differ significantly. The MIG90 values of erythromycin were the same for B. pertussis (MIC90 = 0,125 mg/l) and B.parapertussis strains (MIC 90 = 0,25 mg/l) recovered in 1968 as for those recovered in the years 1997-99. The most active antibiotic against all strains was azithromycin (MIC90 = 0,06 mg/l). The least active antibiotics were oleandomycin (MIC90 = 2-4 mg/l) and spiramycin (MIC90 = 8 mg/I). The study showed that erythromycin remains the antibiotic of choice for treatment of whooping cough and in case of emergence of B. pertussis and/or B. parapertussis strains erythromycin resistant, can be replaced by azithromycin.

Słowa kluczowe

PL

opornosc na erytromycyne; parakrztusiec; choroby czlowieka; krztusiec; erytromycyna; Bordetella parapertussis; antybiotyki makrolidowe; bakterie; wrazliwosc na antybiotyki; Bordetella pertussis

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2001
• Tom: 53
• Numer: 1
• Opis fizyczny: s.39-43,tab.,bibliogr.

Twórcy

autor

Chodorowska M.

• Panstwowy Zaklad Higieny, 00-791 Warszawa, ul.Chocimska 24

autor

Kuklinska D.

autor

Tyski S.

Bibliografia

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• 2. Bryskier A, Butzler J-P. Macrolides. W: Antibiotic and chemotherapy: antiinfective agents and their use in therapy. Red. F. O'Grady, HP. Lambert, RG. Finch, D. Greenwood, Churchill Livingstone, New York, 1997, 377-93.
• 3. Hoppe JE, Bryskier A. In vitro susceptibilities of Bordetella pertussis and B. parapertussis to two ketolides (HMR 3004 and HMR 3647), four macrolides (azithromycin, clarithromycin, erythromycin A, and roxithromycin), and two ansamycin (rifampin and rifapentine). Anti¬microb Agents Chemother 1998; 42: 965-66.
• 4. Hoppe JE, Tschirner T. Comparison of media for agar dilution susceptibility testing of Bordetella pertussis and Bordetella parapertussis. Eur J Clin Microbiol Infect Dis 1995; 14: 775-79.
• 5. Korgenski EK, Daly JA. Surveillance and detection of erythromycin resistance in Bordetella pertussis isolates recovered from a pediatric population in the Intermountain West Region of the United States. J Clin Microbiol 1997; 35: 2989-91.
• 6. Kurzynski TA, Boehm DM, Rott-Petri JA i inni. Antimicrobial susceptibilities of Bordetella pertussis species isolated in a multicenter pertussis surveillance project. Antimicrob Agents Chemother 1988; 32: 137-40.
• 7. Lewis S, Erickson B, Cage G i inni. Erythromycin-resistant Bordetella pertussis - Yuma County, Arizona. MMWR 1994; 43: 807-10.
• 8. Wiedemann B, Grimm H. Susceptibility to antibiotics, species incidence and trends. W: Antibiotics in laboratory medicine. Red. V. Lorian, Williams & Wilkins, Baltimore, 1996, 900-1168.