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1990 | 41 | 7 |

Tytuł artykułu

Amino acid - induced insulin release from the perfused rat pancreas. The influence of phenylalanine and tyrosine

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Maćkowiak P.: Amino acid-induced insulin release from the perfused irat pancreas. The influence of phenylalanine and tyrosine. Acta physiol, pol. The effects of L or D phenylalanine and L tyrosine on insulin release from the perfused rat pancreas were investigated. It was found that in the presence of D-glucose, all three amino-acids stimulate insulin secretion. After L-Phe had been removed from perfusate in the presence or absence of L-Tyr, the secondary rise of insulin release (an “off response”) was noticed. This phenomenon did not follow to either D-Phe or L-Tyr.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

41

Numer

7

Opis fizyczny

p.169-175,fig.,ref.

Twórcy

autor
  • Department of Animal Physiology and Biochemistry, Academy of Agriculture, Wolynska 35, 60-637 Poznan, Poland

Bibliografia

  • 1. Assan R., Attali J. R., Ballerio G., Boillot J., Girard J. R. (1977): Glucagon secretion induced by natural and artificial amino acids in the perfused rat pancreas. Diabetes, 26, 300-307.
  • 2. Davis S. L. (1972): Plasma levels of prolactin, growth hormone, and insulin in sheep following the infusion of arginine, leucine and phenylalanine.
  • 3. Embden G., Baldes К. (1913): Über den Abbau des Phenylalanins in tierischen Organismus. Biochem. Z., 55, 301-322.
  • 4. Florkin M. (1975): From amino acids to the tricarboxylic acid cycle. In: A History of Biochemistry, eds. M. Florkin, E. H. Stotz, vol. 31, pp. 336-346. Elsevier Scientific Publishing Company, Amsterdam-Oxford-New York.
  • 5. Floyd J. C., Fajans S. S., Conn J. W., Knopf R. F., Rull J. (1966): Stimulation of insulin secretion by amino acids. J. Clin. Invest., 45, 1487-1502.
  • 6. Hjeml M., Kitney R., Lindsey P., Seakins J. (1984): Computer model of the metabolism of phenylalanine in normal subjects and in patients with phenylketonuria. Comp. Prog. Biomed., 18, 21-32
  • 7. Landgraf R., Landgraf-Leurs M. M. C., Hörl R. (1974). L-leucine and L-phenyl-alanine induced insulin release and the influence of D-glucose. Kinetic studies with the perfused rat pancreas. Diabetologia, 10, 415-420.
  • 8. Malaisse W. J., Malaisse-Lagae F. (1968): Stimulation of insulin secretion by noncarbohydrate metabolites. J. Lab. Clin. Med., 72, 438-448.
  • 9. Реk S., Santiago J. C. (1978): L-Leucine - induced secretion of glucagon and insulin, and the “off-response” to L-leucine in vitro. I. Characterization of the dynamic of secretion. Endocrinology, 103, 1208-1218.
  • 10. Penhos J. C., Wu Ch. H., Basabe J. C., Lopez N., Wolff F. W. (1969): A rat pancreas-small gut preparation for the study of intestinal factor(s) and insulin release. Diabetes, 18, 733-738.
  • 11. Rocha D. M., Faloona G. R., Unger R. H. (1972). Glucagon-stimulating activity of 20 amino acids in dogs. J. Clin. Invest., 51, 2346-2351.
  • 12. Sener A., Kawazu S., Hutton J. C., Boschero A. C., Devis G., Somers G., Herchuelz A., Malaise W. J. (1978); The stimulus secretion coupling of glucose-induced insulin release. XXXIII. Effect of exogenous pyruvate on islets function. Blochem. J., 176, 217-226.
  • 13. Sener A., Malaisse W. J. (1984): Inhibition by L-valine and L-norleucine of 3-phenylpyruvate — induced insulin release. Biochemie, 66, 353-360.
  • 14. Tai T. Y., Реk S., Santiago J. C. (1978): L-leucine induced secretion of glucagon and insulin and the “off-response” to L-leucine in vitro. II. The role of D-glucose. Endocrinology, 103, 1219-1226.
  • 15. Uderfiend S., Cooper J. R. (1952): The enzymatic conversion of phenylalanine to tyrosine. J. Biol. Chem., 194, 503-511.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-afa2d49d-82b5-4035-8cc5-377fc7c2b545
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