Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats

• Autorzy: Lee K. H. , Suh-Kim H. , Choi J. S. , Jeun S.-S. , Kim E. J. , Kim S.-S. , Yoon D. H. , Lee B. H.
• Języki publikacji: EN

Abstrakty

EN

Many attempts have been made in animals to produce cellular regeneration in the spinal cord using a variety of transplanted cell types. The present study was to investigate whether transplantation of human mesenchymal stem cells (hMSCs) into the spinal cord after contusion injury promotes a functional outcome. Spinal cord injury (SCI) was induced using an NYU impactor and hMSCs were transplanted 1 week after SCI. Behavioral testing was performed weekly for 2 months. Somatosensory (SSEPs) and motor evoked potentials (MEPs) were recorded to determine functional recovery. Hindlimb performance was modestly improved in the transplanted group based on BBB scaling and pain tests. SSEP latencies in the transplanted group were significantly shorter than in the media-treated group. Pathologically, LacZ and hTau positive cells were located at the injury and adjacent sites. The data indicate improvement in functional outcome in animals treated with hMSC transplantation compared to media-treated animals.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2007
• Tom: 67
• Numer: 1
• Opis fizyczny: p.13-22,fig.,ref.

Twórcy

autor

Lee K. H.

• Department of Physiology and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
• Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea

autor

Suh-Kim H.

• Department of Anatomy and Brain Disease Research Center, School of Medicine, Ajou University, Suwon 443-721, Korea

autor

Choi J. S.

• Department of Physiology and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
• Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea

autor

Jeun S.-S.

• Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea

autor

Kim E. J.

• Department of Physiology and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
• Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea

autor

Kim S.-S.

• Department of Anatomy and Brain Disease Research Center, School of Medicine, Ajou University, Suwon 443-721, Korea

autor

Yoon D. H.

• Department of Neurosurgery, Yonsei University College of Medicine, Seoul 120-752, Korea

autor

Lee B. H.

• Department of Physiology and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea
• Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea

Uwagi

PL

Rekord w opracowaniu