Downregulated canine testis and recrudescence of testicular function following abolition of downregulation

• Autorzy: Hoffmann B. , Goericke-Pesch S.
• Języki publikacji: EN

Abstrakty

EN

The method of choice for the downregulation of canine testicular function is the use of slow-release GnRHagonist implants. Clinical efficacy has well been demonstrated, and basic information on the underlying mechanisms of action has been obtained. As reviewed in the present paper, the treatment-induced decreased availability of LH is followed by the downregulation of the steroidogenic apparatus and – restricted to the protein level – of androgen receptor expression. A downregulated testis is distinctly different from a juvenile one and rather resembles the situation observed in testes of seasonally breeding animals out of season. Following the abolition of downregulation, the onset and recrudescence of testicular function is a rapid process. Full steroidogenic capacity is regained within 3 weeks, and spermatogenesis enters the spermatogenic cycle leading to pre-treatment ejaculate quality.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2014
• Tom: 70
• Numer: 09
• Opis fizyczny: p.515-519,fig.,ref.

Twórcy

autor

Hoffmann B.

• Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35398 Giessen, Germany

autor

Goericke-Pesch S.

• Department of Large Animal Science, Section of Veterinary Reproduction, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 68, Fredriksberg C, Denmark

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