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2009 | 69 | 3 |
Tytuł artykułu

The involvement of nutric oxide (NO) in the amnesic effects of diazepam in mice

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Literature data show the relationship between L-arginine:NO:cGMP pathway and g-aminobutyric acid (GABA)-mediated transmission in the central nervous system. Benzodiazepines are known to enhance the GABA-ergic neurotransmission and well established as inhibitory modulators of memory processing. More-over, the role of NO in learning and memory processes has been proposed. The present studies were designed to evaluate the role of L-arginine:NO:cGMP pathway in the amnesic effects of diazepam (DZ) in the modifi ed elevated plus-maze (mEPM) task in mice. Our experiments indicated that DZ (1 mg/kg, s.c.) impaired elevated plus-maze memory performance in mice. Pretreatment with L-arginine, the NO precursor, (500 mg/kg, i.p.) prevented the amnesic properties of DZ. While, 7-nitroindazole (7-NI), the neuronal NO synthase inhibitor (nNOS), (40 mg/kg, i.p.) and methylene blue (MB), the soluble guanylate cyclase (sGC) inhibitor, (5 mg/kg, i.p.) enhanced the DZ-induced memory defi cits. Moreover, the effect of both 7-NI and MB were reversed by L-arginine (250 mg/kg, i.p.). It is important to note that presented data are not due to either 7-NI-, MB-induced impairment of memory or changes in locomotor activity, because 7-NI and MB given alone, had no impact on the mEPM behaviour and locomotor activity of mice. Taken together, these results suggest that an inhibition of the Larginine:NO:cGMP pathway may be involved in the amnesic effects of benzodiazepines.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.353-354
Twórcy
autor
  • Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
autor
  • Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
autor
  • Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
autor
  • Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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