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2017 | 77 | Suppl.1 |
Tytuł artykułu

Anticonvulsant effect of resveratrol in the conditions of acute pentilentetrazol-induced seizures

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INTRODUCTION: The incidence of seizure syndromes including those epilepsy associated actualizes the search of new anticonvulsants. Resveratrol has antioxidant, cardioprotective, anti-cancer and neuroprotective properties. It was also shown that resveratrol can be used as the drug reducing the risk of chronic epilepsy. AIM(S): The objective of this study was to evaluate the effect of resveratrol on acute seizure activity induced by intravenous pentylenetetrazol administration. METHOD(S): To study the anticonvulsant effect, young male mice, weighing 18–20 g, CBA line kept in standard vivarium conditions, were used. The introduction of trans-resveratrol was carried out orally in a dose of 50, 100 and 200 mg/kg. Acute seizure activity was induced by administration of 0.1% aqueous pentylenetetrazol solution in the tail vein 30, 90 and 120 minutes after the administration of resveratrol. The effect of the anticonvulsant action of resveratrol was assessed by the changes in minimum pentylenetetrazol dose causing clonic-tonic convulsions (DCTC) and tonic extension (DCE) in the experimental animals. Efficient pentylenetetrazol doses for experimental groups of animals are expressed in % of similar pentylenetetrazol doses causing clonic-tonic convulsions and tonic extensions in the control group. RESULTS: Resveratrol administration with about 30 minutes exposure increased in the same way DCTC and DCE parameters for all doses studied. Thus, DCTC was by 36–45% bigger and DCE by 41–56% bigger than the corresponding parameters in the control group of animals. When resveratrol is administered at 90 and 120 minutes, the most pronounced anticonvulsant effect was fixed for the dose of 200 mg/kg (DCTC – 188%, DCE – 195%). For the doses of 50 and 100 mg/kg at 90 and 120 minute exposure, the anticonvulsant effect was 12–25% lower than for the dose of 200 mg/kg. CONCLUSIONS: The findings in present study by suggest an antiepileptic potential of resveratrol in chronic condition or in other seizure model.
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  • Department of Physiology, Odessa National Medical University, Odessa, Ukraine
  • Department of Physiology, Odessa National Medical University, Odessa, Ukraine
  • Department of Physiology, Odessa National Medical University, Odessa, Ukraine
  • Department of Pharmaceutical Chemistry, Odessa National University Mechnikova I.I., Odessa, Ukraine
  • Department of Organic and Pharmaceutical Technology, Odessa National Politechnical University, Odessa, Ukraine
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