Subpulation of lymphocytes CD4+and CD8+ in peropheral blood of sheep with zearalenone mycotoxicosis

• Autorzy: Kostro K. , Gajecka M. , Lisiecka U. , Majer-Dziedzic B. , Obremski K. , Zielonka L. , Gajecki M.
• Języki publikacji: EN

Abstrakty

EN

In sheep raised in chamber system and fed concentrate fodder containing high dose of zearalenone and its metabolite (α- zearalenol), the clinical course of zearalenonosis was diagnosed. Control animals were kept on grazing-land from the spring to the late autumn, and only in winter time they were fed shredded wheat with the lowest concentration of zearalenone. These sheep showed no clinical symptoms of the mycotoxicosis. Zearalenone and α-zearalenol cause immunosuppression, which means that lymphocyte T CD4+ and lymphocyte T CD8+ percentages decline and CD4/CD8 ratio increases when compared with control animals. Zearalenone mycotoxin suppression effect modulates cellular immunological response, which is essential in suppression of post-vaccination immunity and infectious diseases development despite applying normal specific immunoprophylaxis.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2011
• Tom: 55
• Numer: 2
• Opis fizyczny: p.241-246,fig.,ref.

Twórcy

autor

Kostro K.

• Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Poland

autor

Gajecka M.

autor

Lisiecka U.

autor

Majer-Dziedzic B.

autor

Obremski K.

autor

Zielonka L.

autor

Gajecki M.

Bibliografia

• 1. Ben Salah-Abbes J., Abbes S., Houas Z., Abdel-Wahhab M., Oueslati R.: Zearalenone induces immunotoxicity in mice: possible protective effects of radish extract (Raphanus sativus). J Pharm Pharmacol 2008, 60, 761- 770.
• 2. Bovee T.F.H., Heisdingen R.J.R., Rietjens I.M.C.M., Keijer J., Hoogenboom R.L.A.P.: Rapid yeast estrogen bioassays stably expressing human estrogen receptors α and ß, and green fluorescent protein: a comparison of different compounds with both receptor types. J Steroid Biochem Mol Biol 2004, 91, 99-109.
• 3. Chen J.-Q., Yager J.D., Russo J.: Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications. Biochim Biophys Acta - Mol Cell Res 2005, 1746, 1-17.
• 4. Dänicke S., Ueberschar K.H., Halle I., Matthes S., Valenta H., Flachowsky G.: Effect of a detoxifying agent to laying hen diets containing uncontaminated or Fusarium toxin-contaminated maize on performance of hens and carryover of zearalenone. Poultry Sci 2002, 81, 1671-1680.
• 5. Dänicke S., Valenta H., Doll S.: On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Arch Animal Nutr 2004, 58, 169-180.
• 6. Dombrink-Kurtzman M.A., Gomez-Flores R., Weber R.J.: Activation of rat splenic macrophage and lymphocyte functions by fumonisin B₁. Immunopharmacology 2000, 49, 401-409.
• 7. Eriksen G.S., Pettersson H., Lindberg J.E.: Absorption, metabolism and excretion of 3-acetyl DON in pigs. Arch Animal Nutr 2003, 57, 335-345.
• 8. Gajęcki M., Gajęcka M., Zielonka Ł., Jakimiuk E., Obremski K.: Zearalenone as a potential allergen in the alimentary tract - a review. Pol J Food Nutr Sci 2006, 56, 263-268.
• 9. Kaech S.M., Wherry E.J., Ahmed R.: Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol 2002, 2, 251-262.
• 10. Kimura M., Takahasi-Ando N., Nishiuchi T., Ohsato S., Tokai T., Ochiai N., Fujimura M., Kudo T., Hamamoto H., Yamaguchi I.: Molecular biology and biotechnology for reduction of Fusarium mycotoxin contamination. Pestic Biochem Physiol 2006, 86, 117-123.
• 11. Kollarczik B., Gareis M., Hanelt M.: In vitro transformation of the Fusarium mycotoxins deoxynivalenol and zearalenone by the normal gut microflora of pigs. Nat Toxins 1994, 2, 105-110.
• 12. Kuciel-Lisieska G.: The presence of zearalenone in women with neoplastic lesions in mammary gland Doctoral thesis. Faculty of Medicine, Medical University in Warsaw, Warsaw, 2006.
• 13. McGeown J.G., Crockard A.D.: Lymphocyte subsets recirculate from blood to lymph at different rates in conscious sheep. Biomed Life Sci 1993, 422, 533-535.
• 14. Obremski K., Gajęcki M., Otrocka-Domagała I., Rotkiewicz T., Zwierzchowski W., Zielonka Ł., Mikołajczyk A., Siemionek J.: Clinical case of rabbit zearalenone mycotoxicosis Medycyna Wet 2005, 61, 361-480.
• 15. Obremski K., Gajęcki M., Zwierzchowski W., Zielonka Ł., Skorska-Wyszyńska E., Gajęcka M., Polak M., Jakimiuk E., Wojciechowski J.: Clinical and laboratory diagnosis of zearalenone mycotoxicoses in gilts Medycyna Wet 2004, 60, 785-896.
• 16. Romagnani S.: Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease. Int J Clin Lab Res 1991, 21, 152-159.
• 17. Stahl S., Chun T.Y., Gray W.G.: Phytoestrogens act as estrogen agonists in an estrogen-responsive pituitary cell line. Toxicol Appl Pharmacol 1998, 152, 41-48.
• 18. Stoev S.D., Goundasheva D., Mirtcheva T., Mantle P.G.: Susceptibility to secondary bacterial infections in growing pigs as an early response in ochratoxicosis. Exp Toxicol Pathol 2000, 52, 287-296.
• 19. Taranu I., Marin D.E., Bouhet S., Pascale F., Bailly J.- D., Miller J.D., Pinton P., Oswald I.P.: Mycotoxin fumonisin B₁ alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol Sci 2005, 84, 301-307.
• 20. Yiannikouris A., Jouany J.P.: Mycotoxins in feeds and their fate in animals: a review. Anim Res 2002, 51, 81- 99.
• 21. Wollenhaupta K., Jonas L., Tiemann U., Tomek W.: Influence of the mycotoxins α- and ß-zearalenol (ZOL) on regulators of cap-dependent translation control in pig endometrial cells. Reprod Toxicol 2004, 19, 189-199.
• 22. Vlata Z., Porichis F., Tzanakaki G., Tsatsakis A., Krambovitis E.A.: Study of zearalenone cytotoxicity on human peripheral blood mononuclear cells. Toxicol Lett 2006, 165, 274-281.
• 23. Zinedine A., Soriano J.M., Moltó J.C., Mañes J.: Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic micotoxin. Food Chem Toxicol 2007, 45, 1-18.
• 24. Zwierzchowski W., Obremski K., Zielonka Ł., Skorska- Wyszyńska E., Gajęcka M., Jakimiuk E., Polak M., Jana B., Rybarczyk L., Gajęcki M.: The impact of zearalenone on the level of the selected estrogens in blood serum of sexually immature gilts. Pol J Vet Sci 2006, 9, 247-252.