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2009 | 69 | 3 |
Tytuł artykułu

Cortical feedback modulates temporal pattern of spontaneous neuronal activity in the cat's dorsal lateral geniculate and perigeniculate nuclei

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In cats with pretrigeminal brainstem transections, reversible inactivation of the primary visual cortex by cooling results in changes of the magnitude of response and spatio-temporal structure of receptive fi elds of neurons from lateral geniculate and perigeniculate nuclei (LGNd and PGN; Waleszczyk et al. 2005). Since cortical inactivation changes also the spontaneous activity of these thalamic neurons, we hypothesized that cortical feedback affects their membrane potential. Both types of investigated cells displayed two modes of activity: a tonic mode, during depolarization; and a burst mode, when the cell is hyperpolarized. In this report we investigated the effect of elimination of cortical feedback by cooling on the temporal pattern of the spontaneous "bursty" activity of single neurons in LGNd and PGN. During such reversible inactivation of areas 17 and 18, in both LGNd and PGN cells, spontaneously occurring bursts exhibited longer interspike intervals (ISIs) and lower number of spikes, while the average burst duration remained unchanged. Longer ISIs suggest that cortical feedback infl uences not only visual responsiveness of thalamic neurons, but also temporal pattern of their spontaneous fi ring, in line with the hypothesis of a tonic cortical modulation of their membrane potential. Supported by the Ministry of Science and Higher Education grant COST/127/2007.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.324
Twórcy
  • Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-a9a41d9d-18cb-46f7-94f6-e9f349462516
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