Cognitive judgment bias in the cocaine-induced model of mania in rats

• Autorzy: Kubik J. , Golebiowska J. , Kregiel J. , Rygula R.
• Języki publikacji: EN

Abstrakty

EN

Chronic psychostimulant administration is a frequently used, however unspecific, model of mania in rodents. In our study, we investigated whether chronic administration of cocaine may produce in rats, also more specific, cognitive symptoms of mania, such as the hyperoptimistic cognitive judgment bias. To accomplish this goal, after initial behavioral training, 2 groups of rats were subjected either to 2 weeks of chronic cocaine treatment or physiological saline injections. Before and after the treatment the animals were tested with ambiguous-cue interpretation paradigm. We report that chronic cocaine administration does not produce optimistic judgment bias in rats. Supported by the National Science Centre (Research grant: Sonata bis dec-2012/07/E/NZ4/00196) and the statutory funds of the Institute of Pharmacology PAS.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.359

Twórcy

autor

Kubik J.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland

autor

Golebiowska J.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland

autor

Kregiel J.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland

autor

Rygula R.

• Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland