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2013 | 16 | 1 |

Tytuł artykułu

Anthelmintics residues in raw milk. Assessing intake by a children population

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Anthelmintics, such as benzimidazoles and probenzimidazoles, are veterinary drugs used against endoparasites in food producing animals. A number of these drugs are considered responsible for embryotoxicity and teratogenicity. The residue levels of Albendazole, Febantel, Fenbendazole, Mebendazole and some of their metabolites (Albendazole sulphoxide, Albendazole sulphone, Fenbendazole sulfone) were assessed in 123 (42 goat, 69 sheep, 12 bovine) raw milk samples collected from all farms throughout Southern Greece. Sample analysis was performed by HPLC with Diode Array Detector. A high percentage (27.6%) of the samples examined was found to be positive for the investigated compounds. In 14 samples (11.4%), the residues’ concentration exceeded the established Maximum Residue Limits. Estimated Daily Intakes were calculated for a population of 723 children aged 10-12 years. Data on milk consumption were obtained by personal interview through a 7-day food frequency questionnaire. The maximum Estimated Daily Intakes for the anthelmintic residues, concerning raw milk, did not exceed the current Acceptable Daily Intake.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

16

Numer

1

Opis fizyczny

p.85-91,ref.

Twórcy

autor
  • Laboratory of Public Health, Medical School, University of Patras, GR-26 504, Greece
autor
  • Laboratory of Public Health, Medical School, University of Patras, GR-26 504, Greece
  • Laboratory of Public Health, Medical School, University of Patras, GR-26 504, Greece
  • Laboratory of Public Health, Medical School, University of Patras, GR-26 504, Greece

Bibliografia

  • Blasco C, Fernandez M, Picó Y, Font G, Manes J (2002) Simultaneous determination of imidacloprid, carbendazim, methiocarb and hexythiazox in peaches and nectarines by liquid chromatography-mass spectrometry. Anal Chim Acta 461: 109-116.
  • Blasco C, Font G, Manes J, Pico Y (2005) Screening and evaluation of fruit samples for four pesticide residues. J AOAC Int 88: 847-853.
  • Blasco C, Font G, Pico Y (2006) Evaluation of 10 pesticide residues in oranges and tangerines from Valencia (Spain). Food Control 17: 841-846.
  • Botsoglou NA, Fletouris DJ (2000) Consumer perceptions and concerns. In: Fletouris DJ, Botsoglou NA (eds) Drug Residues in Foods. Pharmacology, Food Safety, and Analysis. CRC Press, pp 541-548.
  • Capleton AC, Courage C, Rumsby P, Holmes P, Stutt E, Boxall AB, Levy LS (2006) Prioritising veterinary medicines according to their potential indirect human exposure and toxicity profile. Toxicol Lett 163: 213-223.
  • Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin (2010) http://ec.europa.eu/health/ files/eudralex/vol-5/reg–2010–37/reg–2010–37–en.pdf
  • Cooper KM, Whelan M, Danaher M, Kennedy DG (2011) Stability during cooking of anthelmintic veterinary drug residues in beef. Food Addit Contam A 28: 155-165.
  • Delatour P, Garnier F, Benoit E (1983) Kinetics of four metabolites of febantel in cow’s milk. Vet Res Commun 6: 37-42.
  • De Liguoro M, Longo F, Brambilla G, Cinquina A, Bocca A, Lucisano A (1996) Distribution of the anthelmintic drug albendazole and its major metabolites in ovine milk and milk products after a single oral dose. J Dairy Res 63: 533-542.
  • De Ruyck H (2003) Development of confirmatory methods and disposition of some veterinary drugs in food. [PhD thesis] Gent University. https://biblio.ugent.be/input/download?func=downloadFile&recordOId=521757& fileOId=1874959
  • EMEA (European Medicines Agency) (1999) Committee for Veterinary Medicinal Products: Albendazole Oxide – summary report 2. http://www.ema.europa.eu/docs/en–GB/document–library/Maximum–Residue–Limits–-–Report/2009/11/WC500009687.pdf
  • EMEA (European Medicines Agency) (2004a) Committee for Veterinary Medicinal Products: Febantel – summary report 4. http://www.emea.europa.eu/pdfs/vet/mrls/086703en.pdf
  • EMEA (European Medicines Agency) (2001) Committee for Veterinary Medicinal Products: Mebendazole – summary report 2. http://www.emea.europa.eu/pdfs/vet/mrls/078101en.pdf
  • EMEA (European Medicines Agency) (2004b) Committee for Veterinary Medicinal Products: Fenbendazole (Extrapolation to all ruminants) – summary report 4. http://www.ema.europa.eu/docs/en–GB/document–library/Maximum–Res idue–Limits–-–Report/2010/07/WC500094856.pdf
  • EMEA (European Medicines Agency) (2004c) Committee for Veterinary Medicinal Products: Albendazole (Extrapolation to all ruminants) – summary report 3. http://www.emea.europa.eu/pdfs/vet/mrls/086503en.pdf
  • Fletouris DJ, Botsoglou NA, Psomas IE, Mantis AI (1997a) Determination of the marker residue of albendazole in milk using ion-pair liquid chromatography and fluorescencedetection. Anal Chim Acta 345: 111-119.
  • Fletouris DJ, Botsoglou NA, Psomas IE, Mantis AI (1997b) Determination of the marker residue of albendazole in cheese by ion-pair liquid chromatography and fluorescence detection. J Dairy Sci 80: 2695-2700.
  • Fletouris DJ, Botsoglou NA, Psomas IE, Mantis, AI (1998) Albendazole-related drug residues in milk and their fate during cheesemaking, ripening, and storage. J Food Prot 61: 1484-1488.
  • Friar PM, Reynolds SL (1991) The effects of microwave- baking and oven-baking on thiabendazole residues in potatoes. Food Addit Contam 8: 617-626.
  • Higa F, Kitsukawa K, Gaja M, Tateyama M, Shikiya K, Shigeno Y, Kinjo F, Saito A (1992) Cytotoxicity of mebendazole against established cell lines from the human, rat, and mouse liver. Arch Toxicol 66: 224-227.
  • McKellar QA, Scott EW (1990) The benzimidazole anthelmintic agents: a review. J Vet Pharmacol Ther 13: 223-247.
  • Nuray A, Orenay S, Reyhan E, Turk M, Asci M, Turel S, Yolasigmaz A, Nazmiye A (2007) Genotoxic effects of albendazole in patients medicated for cystic echinococcosis. Helminthologia 44: 57-61.
  • Oztas S, Salman AB, Tatar A, Yigiter M, Yazgi H, Ertek M, Yesilyurt A, Ocak Z, Kursad H (2007) Genotoxic effect of albendazole in pediatric patients with hepatic hydatid disease. Int J Infect Dis 11: 446-449.
  • Ramırez T, Benıtez-Bribiesca L, Ostrosky-Wegman P, Herrera LA (2001) In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes. Arch Med Res 32: 119-122.
  • Rose MD, Shearer G, Farrington WH (1997) The effect of cooking on veterinary drug residues in food; 5. Oxfendazole. Food Addit Contam 14: 15-26.
  • Roumelioti M, Leotsinidis M (2009) Relative validity of a semiquantitative food frequency questionnaire designed for schoolchildren in western Greece. Nutr J 8: 8.
  • Su SC, Chang CL, Chang PC, Chou SS (2003) Simultaneous determination of albendazole, thiabendazole, mebendazole and their metabolites in livestock by high performance liquid chromatography. J Food Drug Anal 11: 307-319.
  • Takeba K, Fujinuma K, Sakamoto M, Miyazaki T, Oka H, Itoh Y, Nakazawa H (2000) Simultaneous determination of triclabendazole and its sulphoxide and sulphone metabolites in bovine milk by high-performance liquid chromatography. J Chromatogr A 882: 99-107.
  • Tsiboukis D, Sazakli E, Gortzi O, Hadjichristodoulou C, Matara C, Leotsinidis M (2010) Assessing quality of raw milk in southern Greece in the aspect of certain benzimidazole residues. Food Addit Contam B Surveill 3: 73-79.

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Bibliografia

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