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2009 | 69 | 3 |
Tytuł artykułu

Colocalisation of glucocorticoid and 5-HT1A receptor immunoreakrivity-expressing cells in the brain structures of low and high anxiety rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In recent years we have elaborated an animal model to examine the neurochemical background of differences in the individual responses to conditioned aversive stimuli, using the strength of a rat contextual fear test, as a discriminating variable: low responders (LR), i.e. rats with duration of a freezing response one standard error, or more, below the mean value and high responders (HR), i.e. rats with duration of a freezing response one standard error, or more, above the mean value. It was found that 1.5 h after a testing session of contextual fear test, the LR animals showed a higher density of 5-HT1A and glucocorticoid immunoreactivity-expressing cells (GRsir) in the cortical M2 area and hippocampal dentate gyrus as well as an increased number co-expressing 5-HT1A /GRs-ir in the same areas. The HR rats had a signifi cantly higher concentration of 5-HT1A and GRs-ir in the basolateral amygdala. The present data add more arguments for the neurobiological background of differences in individual responses to aversive conditioned stimuli.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.369
Twórcy
autor
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
  • Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
autor
  • Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
autor
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
autor
  • Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-9dfe5473-080b-4a74-b87f-190b44762df4
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