Serum ferritin, iron and transferrin in women with thyrotoxic Graves' disease before and after methimazole treatment

• Autorzy: Zwirska-Korczala K. , Buntner B. , Sobieraj H. , Ostrowska Z. , Kniazewski B. , Swietochowska E.
• Języki publikacji: EN

Abstrakty

EN

Żwirska-Korczala K., Buntner В., Sobieraj H., Ostrowska Z., Kniażewski B. and Świętochowska E.: Serum ferritin, iron and transferrin in women with thyrotoxic Graves’ disease before and after methimazole treatment. Acta physiol, pol., 1990, 41 (2): 166-166. We investigated iron metabolism in 47 women with thyrotoxic Graves’ disease. Serum iron, ferritin, transferin, triiodothyronine and thyroxine concentrations were RIA measured before and after methimazole treatment when patients became euthyroid. The control group consisted of 52 healthy women. We noted that serum ferritin levels and the ferritin to transferrin ration were significantly lower while the iron to ferritin ratio was higher in patients before and after methimazole therapy. Iron concentration as well as the iron to transferrin and the iron to thyroid hormone ratios were decreased only before treatment.

Słowa kluczowe

EN

serum; ferritin; iron; transferrin; woman; thyroid disease; Graves' disease; toxic diffuse goiter zob.Graves' disease; treatment; Flajani-Basedow-Graves disease zob.Graves' disease; methimazole; antithyroid agent

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1990
• Tom: 41
• Numer: 7
• Opis fizyczny: p.163-168,fig.,ref.

Twórcy

autor

Zwirska-Korczala K.

• Department of Pathophysiology and Clinical Analytics, Silesian Medical Academy, Traugutta 2, Zabrze, Poland

autor

Buntner B.

• Department of Pathophysiology and Clinical Analytics, Silesian Medical Academy, Traugutta 2, Zabrze, Poland

autor

Sobieraj H.

• Department of Pathophysiology and Clinical Analytics, Silesian Medical Academy, Traugutta 2, Zabrze, Poland

autor

Ostrowska Z.

• Department of Pathophysiology and Clinical Analytics, Silesian Medical Academy, Traugutta 2, Zabrze, Poland

autor

Kniazewski B.

• Department of Pathophysiology and Clinical Analytics, Silesian Medical Academy, Traugutta 2, Zabrze, Poland

autor

Swietochowska E.

• Department of Pathophysiology and Clinical Analytics, Silesian Medical Academy, Traugutta 2, Zabrze, Poland

Bibliografia

• 1. Addison G. M., Beamish M. R., Halles C. N., Hodgkins M., Jacobs A., Llewlyn P. (1972): An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J. Clin. Pathol., 25, 326-329
• 2. Bodeman H. H., Rieger A., Bross K. J., Schröler-Urban H., Löhn G. W. (1984): Erythrocyte and plasma ferritin in normal subjects blood donors and iron deficiency anemia patients. Blut, 48, 131-137.
• 3. Das K. C., Mukherjee M., Sarkar T. K., Dash R. J., Rastogi G. K. (1975): Erythropoiesis and erythropoietin in hypo- and hyperthyroidism. J. Clin. Endocrinol. Metab., 40, 211-220.
• 4. Donati R. M., Warnecke M. A., Galiagher N. I. (1965): Ferrokinetics in hyperthyroidism. Ann. Intern. Med., 63, 945-950.
• 5. Jacobs A., Worwood M. (1975): The clinical use of serum ferritin estimation. Br. J. Haematol., 31, 1-3.
• 6. Kimber R. J., Rudzki Z., Blunder R. W. (1983): Clinching the diagnosis: Irondeficiency and iron overload: serum ferritin and serum iron in clinical medicine. Pathology, 15, 497-503.
• 7. Krawczyński J., Osiński T. (1967): Laboratoryjne metody diagnostyczne. PZWL, Warszawa, 396-402.
• 8. Macaron С. I., Macaron Z. G. (1982): Increased serum ferritin levels in hyperthyroidism. Ann. Intern. Med., 96, 617-618.
• 9. Mack U., Owens J., Cooksley W. G. E., Powell L. W., Halliday J. W. (1985): The effect of acute liver damage on circulating ferritin levels in vivo and in the isolated perfused rat liver. Br. exp. Path., 66, 185-191.
• 10. Popović W. J., Brown J. E., Adamson J. W. (1977): The influence of thyroid hormones on in vitro erythropoiesis. J. Clin. Invest., 60, 907-913.
• 11. Rivlin R. S., Wagner H. N. (1969): Anaemia in hyperthyroidism. Ann Intern. Med., 70, 507-516.
• 12. Sharma J. C., Roy S. N. (1984): Value of serum ferritin as an index of iron deficiency in elderly anaemic patients. Age Ageing, 13, 248-250.
• 13. Simonin R., Sambuc R., San Marco J. L., Gavelle-Debrosses G. (1983): A new thyrotoxicosis clinical index (calculations basis and applications). Sem. Hop. Paris, 59, 733-741.
• 14. Takamatsu J., Majima M., Miki K., Kuma K., Mozai Т. (1985): Serum ferritin as a marker of thyroid hormone action on peripheral tissue. J. Clin. Endocrinol. Metab., 61, 672-676.
• 15. Van de Vyver F. L., Blockx P. P., Abs R. E., Van den Vogaert W. G., Bekaert J. L. (1982): Serum ferritin levels in hyperthyroidism. Ann. Intern. Med., 97, 930-391.
• 16. Takamatsu J., Majima M., Miki K., Kuma K., Mozai Т. (1985): Serum ferritin as a marker of thyroid hormone action on peripheral tissue. J. Clin Endocrinol. Metab., 61, 672-676.
• 17. Van de Vyver F. L., Blockx P. P., Abs R. E., Van den Vogaert W. G., Bekaert J. L. (1982): Serum ferritin levels in hyperthyroidism. Ann. Intern. Med., 97, 930-931.