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2012 | 56 | 4 |

Tytuł artykułu

Major acute phase proteins in pig serum from birth to slaughter

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Age-related changes in serum concentrations of C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA), and pig major acute phase protein (pig-MAP) were investigated in healthy pigs from birth to slaughter under field conditions. Repeated blood samples were obtained from 60 pigs at ages of 1-19 weeks. Concentrations of acute phase proteins (APP) were measured with the use of commercial ELISA kits. Concentrations of all APP increased with age (P<0.05) and positive correlations were evidenced between their concentrations and the age of pigs. Great variations in CRP, Hp, and SAA concentrations were found, as can been seen from standard deviation values. The minimal individual variability was found in regard to pig-MAP. A significant increase in all APP was observed in pigs' serum after weaning, constituting an important characteristic of this period. The elevation of APP after weaning may be associated with stress induced by mixing animals after weaning or changes in the pattern of feed administration. The peak in APP may be also caused by the initiation of synthesis of these proteins by piglets. Because a significant association between age and APP concentrations exists, further studies are needed to decide whether the age may influence the diagnostic value of APP as a marker of infection. Additionally, studies are needed to estimate whether the APP response in infection is age-dependent to any clinical importance degree.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

56

Numer

4

Opis fizyczny

p.553-557,ref.

Twórcy

  • Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland
  • Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

  • 1. Carpintero R., Alonso C., Piñeiro M., Iturralde M., Andres M., La Potier M.F., Madec F., Alava M.A., Piñeiro A., Lampreave F.: Pig major acute phase protein and apolipoprotein A-I responses correlate with clinical course of experimentally induced African swine fever and Aujeszky's disease. Vet Rec 2007, 38, 741-753.
  • 2. Chen H.H., Lin J.H., Fung H.P., Ho L.L., Yang P.C., Lee W.C., Lee Y.P., Chu R.M.: Serum acute phase proteins and swine health status. Can J Vet Res 2003, 67, 283- 290.
  • 3. Clapperton M., Bishop S.C., Cameron N.D., Glass E.J.: Association of acute phase protein levels with growth performance and with selection for growth performance in Large White pigs. Anim Sci 2005, 81, 213-220.
  • 4. Grau-Roma L., Heegaard P.M.H., Hjulsager C.K., Sibila M., Kristensen C.S., Allepuz A., Piñeiro M., Larsen L.E., Segalés J., Fraile L.: Pig-major acute phase protein and haptoglobin serum concentrations correlate with PCV2 viremia and the clinical course of post-weaning multisystemic wasting syndrome. Vet Microbiol 2006, 138, 53-61.
  • 5. Heegaard P.M.H., Klausen J., Nielsen J.P., Gonzalez- Ramon N., Piñeiro M., Lampreave F., Alava M.A. The porcine acute phase response to infection with Aclinobacillus pleuropneumoniae. haptoglobin, C- reactive protein, major acute phase protein and serum amyloid A protein are sensitive indicators of infection. Comp Biochem Physiol 1998, 119B, 365-373.
  • 6. Heegaard P.M.H., Stockmarr A., Piñeiro M., Carpintero R., Lampreave F., Campbell F.M., Eckersall P.D., Toussaint M.J.M., Gruys E., Sorensen N.S.: Optimal combinations of acute phase proteins for detecting infectious disease in pigs. Vet Res 2011, 42, 50-62.
  • 7. Hulten C., Johansson E., Fossum C., Wallgren P.: Interleukin 6, serum amyloid A and haptoglobin as markers of treatment efficacy in pigs experimentally infected with Aclinobacillus pleuropneumoniae. Vet Microbiol 2003, 95, 75-89.
  • 8. Hutchinson W.L., Koenig W., Fröhlich M., Sund M., Lowe G.D., Pepys M.B.: Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population. Clin Chem 2000, 46, 934-938.
  • 9. Lampreave F., González-Ramón N., Martínez-Ayensa S., Hernández M.A., Lorenzo H.K., García-Gil A., Piñeiro A.: Characterisation of the acute phase serum protein response in pigs. Electrophoresis 1994, 15, 672-676.
  • 10. Lauritzen B., Lykkesfeldt J., Skaanild M.T., Angen Ø., Nielsen J.P., Friis C.: Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillns pleuropneumoniae infection. Res Vet Sci 2003, 74, 261-270.
  • 11. Lipperheide C., Diepers N., Lampreave F., Alava M., Petersen B.: Nephelometric determination of haptoglobin plasma concentrations in fattening pigs. J Vet Med A 1998, 45, 543-550.
  • 12. Llamas Moya S., Boyle L.A., Lynch P.B., Arkins S.: Age-related changes in pro-inflammatory cytokines, acute phase proteins and cortisol concentrations in neonatal piglets. Neonatology 2007, 91, 44-48.
  • 13. Martin M., Tesouro M.A., Gonzalez-Ramon N., Piñeiro A., Lampreave F.: Major plasma protein in pig serum during postnatal development. Reprod Fert Develop 2005, 17, 439-445.
  • 14. Orro T., Nieminen M., Tamminen T., Sukura A., Sankari S., Soveri T.: Temporal changes in concentrations of serum amyloid-A and haptoglobin and their associations with weight gain in neonatal reindeer calves. Comp Immunol Microb Infect Dis 2006, 29, 79-88.
  • 15. Pallares F.J., Martinez-Subiela S., Seva J., Ramis G., Fuentes P., Bernabe A., Muñoz A., Ceron J.J.: Relationship between serum acute phase protein concentrations and lesions in finishing pigs. Vet J 2008, 177, 369-373.
  • 16. Petersen H.H., Dideriksen D., Christiansen B.M., Nielsen J.P. Serum haptoglobin concentration as a marker of clinical signs in finishing pigs. Vet Rec 2002, 151, 85-89.
  • 17. Petersen H.H., Ersball A.K., Jensen C.S., Nielsen J.P.: Serum-haptoglobin concentration in Danish slaughter pigs of different health status. Prevent Vet Med 2002, 54, 325-335.
  • 18. Pie S., Lalles J.P., Blazy F., Laffitte J., Seve B., Oswald I.P.: Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr 2004, 134, 641-647.
  • 19. Piñeiro C., Morales J., Piñeiro M., Lampreave F., Mateos G.G.: Effects of induced mixing and pen size on performance and serum concentration of acute phase proteins in growing pigs. J Anim Sci 2004, 82, 505.
  • 20. Piñeiro C., Piñeiro M., Morales J., Andrés M., Lorenzo E., del Pozo M., Alava M.A., Lampreave F.: Pig-MAP and haptoglobin concentration reference values in swine from commercial farms. Vet J 2009, 179, 78-84.
  • 21. Pomorska-Mól M.: Acute phase proteins in pigs- the current state of knowledge. Medycyna Wet 2010, 66, 732.
  • 22. Pomorska-Mól.: Acute phase proteins in veterinary medicine: utility in diagnostics and monitoring of health status. Medycyna Wet 2010, 66, 822-826.
  • 23. Pomorska-Mól M., Markowska-Daniel I., Kwit K., Stępniewska K., Pejsak Z.: Kinetics of the response of four positive acute phase proteins in pigs experimentally infected with toxigenic Pasteurella mnltocida. Vet Microbiol 2011, 152, 429-435.
  • 24. Pomorska-Mól M., Urbaniak K., Markowska-Daniel I.: Porcine acute phase protein response to experimental infection with Bordetella bronchiseptica. Bull Vet Inst Pulawy 2011, 55, 371-375.
  • 25. Pomorska-Mól M., Markowska-Daniel I., Pejsak Z.: Acute phase protein response during subclinical infection of pigs with H1N1 swine influenza virus. Vet Microbiol 2012, DOI: 10.1016/j.vetmic.2012.04.030 - in press
  • 26. Richter H.: Haptoglobin bei haussäugetieren. III. Mitteilung: der haptoglobingehalt im blutplasma und- serum von widerkaüern und sweinen unter verschiedenen physiologischen bedingungen. Arch Exp Vet Med 1974, 28, 505-519.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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