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2009 | 69 | 3 |
Tytuł artykułu

Changes of brain-derived neurotrophic factor (BDNF) immunoreactive cells number in hypothalamic nuclei after chronic stress young and aged rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
It is postulated, that brain-derived neurotrophic factor (BDNF) have been implicated in the neurobiological mechanisms underlying brain plasticity after chronic stress. The objective of this study was to evaluate infl uence of chronic stress on brain plasticity measured by BDNF immunoreactivity in brain structures of young (P28) and adult (P360) rats. 26 male Wistar rats were exposed to 15 min daily open fi eld (OF) or forced swim test (FS) during three weeks. Fluorescent immunohistochemistry was used to localize BDNF positive cells in hypothalamic areas connected with stress response: both parvo- and magnocellular divisions of the paraventricular nucleus (PVp and PVm) and the supraoptic nucleus (SO). In animals aged P28 chronic OF i FS stress caused a statistically signifi cant (P<0.001) decline in the number of BDNF-ir cells in both parts of the PV and SO. In contrast, in rats P360 was not observed any change in the number of BDNF-ir cells after chronic OF stimulation compared to control in PVp and SO. In summary: age of rats subjected to chronic stimulation OF FS or stress had an impact on changes in the number of BDNF-ir cells in the tested hypothalamic nuclei.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.363
Twórcy
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal Physiology, University of Gdansk, Gdansk, Poland
Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-96db83b6-9bd2-454f-8f75-2e8ce2067da4
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