Assessing changes in pial artery resistance and subarachnoid space width using a non-invasive method in healthy humans during the handgrip test

• Autorzy: Wszendobyl-Winklewska M. , Frydrychowski A. F. , Winklewski P. J.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to assess the influence of the handgrip test (HGT) on: (1) pial artery pulsation (cc-TQ), (2) subarachnoid space (SAS) width (sas-TQ) and (3) the relationship between peripheral blood pressure (BP), heart rate (HR), cerebral blood flow velocity (CBFV), resistive index (RI), cc-TQ and sas-TQ. The study was performed on 29 healthy volunteers (11 men and 18 women) with a mean age of 29.3 ± SE 4.0. HGT was performed in the sitting position at 30% of maximal voluntary contraction. cc-TQ and sas-TQ were registered using near-infrared transillumination/backscattering sounding (NIR-T/BSS); BP and heart rate (HR) were measured using a Finapres monitor. CBFV and RI were recorded using a transcranial Doppler. A significant reduction in cc-TQ (-34.3%, P<0.0001) and sas-TQ (-12.9%, P<0.001) were observed, while mean arterial pressure and HR increased (+34.8%, P<0.0001 and +7.9%, P<0.0001, respectively). There was no significant change in CBFV (+1.0%) while RI increased (+12.0%, P<0.05). Correlation and regression analysis did not reveal any interdependencies between the investigated variables. HGT evoked a significant increase in pial artery resistance, with a simultaneous decrease in the width of the SAS. A decrease in pial artery compliance should be seen as protective mechanism against acute BP elevation, most likely mediated by sympathetic activation. NIR-T/BSS recordings allowed for non-invasive assessments of changes in pial artery compliance, and were consistent with data from the literature and physiological knowledge.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2012
• Tom: 72
• Numer: 1
• Opis fizyczny: p.80-88,fig.,ref.

Twórcy

autor

Wszendobyl-Winklewska M.

• Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

autor

Frydrychowski A. F.

• Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

autor

Winklewski P. J.

• Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

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