Cyclosporin A treatment in intrinsic canine atopic dermatitis (atopic - like dermatitis): open trial study

• Autorzy: Fujimura M. , Nakatsuji Y. , Ishimaru H.
• Języki publikacji: EN

Abstrakty

EN

In this study, dogs were separated into two groups and treated with immunosuppressant (Cyclosporin A: CsA). The first group was the canine atopic dermatitis (CAD) group, which is similar to extrinsic atopic dermatitis (AD) in humans (treated with a CsA dose of 2.5-5.5 mg/kg, n=8), and the second group was the canine atopic-like dermatitis (ALD) group, which is similar to intrinsic AD in humans (treated with a CsA dose of 2.5-6.5 mg/kg, n=14). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (PRE) and after treatment (POST) to assess the effectiveness of CsA for the two groups. In the CAD group, CADESI-4 showed no change (PRE:79±29, POST:77±28) and out of the eight dogs, no dogs showed complete remission, three dogs showed partial remission, and five dogs showed no effect. Whereas in the ALD group, CADESI-4 showed a significant reduction (PRE: 61±42, POST: 32±25, p<0.01) and out of the 14 dogs, 11 dogs showed complete remission, two dogs showed partial remission, and one dog showed no effect. The results indicate that the immunosuppressant showed effectiveness for the dogs diagnosed with ALD. One dog had to be treated for a year and eight months, which was the longest period in the study, this dog presented with hyperplasia of the lymphoidgland and mammary tumor.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2016
• Tom: 19
• Numer: 3
• Opis fizyczny: p.567-572,fig.,ref.

Twórcy

autor

Fujimura M.

• Fujimura Animal Allergy Hospital Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan

autor

Nakatsuji Y.

• Fujimura Animal Allergy Hospital Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan

autor

Ishimaru H.

• Fujimura Animal Allergy Hospital Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan

Bibliografia

• Archer TM, Fellman CL, Stokes JV, Pinchuk LM, Lunsford KV, Pruett SB, Langston VC, Mackin AJ (2011) Pharmacodynamic monitoring of canine T-cell cytokine responses to oral cyclosporine, J Vet Intern Med 25: 1391-1397.
• Brandt C, Pavlovic V, Radbruch A, Worm M, Baumgrass R (2009) Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis. Allergy 64: 1588-1596.
• Brenninkmeijer EE, Spuls PI, Legierse CM, Lindeboom R, Smitt JH, Bos JD (2008) Clinical differences between atopic and atopiform dermatitis. J Am Acad Dermatol 58: 407-414.
• Favrot C, Steffan J, Seewald W, Picco F (2010) A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 21: 23-31.
• Forsythe P, Paterson S (2014) Ciclosporin 10 years on: indications and efficacy. Vet Rec 174: 13-21.
• Fujimura M (2011) The study of canine atopic dermatitis involving the isolation of dogs. Pol J Vet Sci 14: 273-277.
• Halliwell R (2006) Revised nomenclature for veterinary allergy. Vet Immunol Immunopathol 114: 207-208.
• Hemenway CS, Heitman J (1999) Calcineurin. Structure, function, and inhibition. Cell Biochem Biophys 30: 115-151.
• Hradetzky S, Werfel T, Rosner LM (2015) Autoallergy in atopic dermatitis. Allergo J Int 24: 16-22.
• Kabashima K (2013) New concept of the pathogenesis of atopic dermatitis. Interplay among the barrier, allergy, and pruritus as a trinity. J Dermatol Sci 70: 3-11.
• Karimkhani C, Silverberg JI, Dellavalle RP (2015). Defining intrinsic vs. extrinsic atopic Dermatitis. Dermatol Online J 16. 21 (6).
• Kawano K, Oumi K, Ashida Y, Horiuchi Y, Mizuno T (2013) The prevalence of dogs with lymphocyte proliferative responses to food allergens in canine allergic dermatitis. Pol J Vet Sci 16: 735-739
• McCaffrey PG, Perrino BA, Soderling TR, Rao A (1993) NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J Biol Chem 268: 3747-3752.
• Nuttall T, Reece D, Roberts E (2014) Life-long diseases need life-long treatment: long-term safety of ciclosporin in canine atopic dermatitis. Vet Rec 174: 3-12.
• Okayama T, Matsuno Y, Yasuda N, Tsukui T, Suzuta Y, Koyanagi M, Sakaguchi M, Ishii Y, Olivry T, Masuda K (2011) Establishment of a quantitative ELISA for the measurement of allergen-specific IgE in dogs using anti-IgE antibody cross-reactive to mouse and dog IgE. Vet Immunol Immunopathol 139: 99-106.
• Olivry T, Rivierre C, Jackson HA, Murphy KM, Davidson G, Sousa CA (2002) Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial. Vet Dermatol 13: 77-87.
• Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB; International Committe on Allergic Diseases of Animals (ICADA) (2014) Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)- 4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol 25: 77-85.
• Prince HE, John JK (1986) Cyclosporine inhibits the expression of receptors for interleukin 2 and transferrin on mitogen-activated human T lymphocytes. Immunol Invest 15: 463-472.
• Pucheu-Haston CM, Bizikova P, Eisenschenk MN, Santoro D, Nuttall T, Marsella R (2015) Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis. Vet Dermatol 26: 115-130.
• Pucheu-Haston CM, Eisenschenk MN, Bizikova P, Marsella R, Nuttall T, Santoro (2015) Introduction to the review articles by ICADA on the pathogenesis of atopic dermatitis in dogs. Vet Dermatol 26: 77-78.
• Radowicz SN, Power HT (2005) Long-term use of cyclosporine in the treatment of canine atopic dermatitis. Vet Dermatol 16: 81-86.
• Salowe SP, Hermes JD (1998) Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. Arch Biochem Biophys 355: 165-174.
• Suto A, Suto Y, Onohara N, Tomizawa Y, Yamamoto-Sugawara Y, Okayama T, Masuda K (2014) Food allergens inducing a lymphocyte-mediated immunological reaction in canine atopic-like dermatitis. J Vet Med Sci 77: 251-254.
• Tokura Y (2010) Extrinsic and intrinsic types of atopic dermatitis. J Dermatol Sci 58: 1-7.

Identyfikatory

DOI

10.1515/pjvs-2016-0071