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2015 | 18 | 1 |

Tytuł artykułu

The effects of dietary deoxynivalenol (DON) on selected blood biochemical and hematological parameters in pre-pubertal gilts

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to determine whether exposure to low doses of DON leads to changes in serum hematological and biochemical profiles. In the experiment, pre-pubertal gilts (with body weight of up to 25 kg) were administered DON per os at a daily dose of 12 |ig/kg BW (group E, n=18) or a placebo (group C, n=21) over a period of 42 days. Blood for analysis was sampled seven times at weekly intervals. Minor, but statistically significant changes were observed in selected indicators, particularly in weeks 2 and 3 in values of biochemical parameters such AlAT, AspAT, Pin and Fe, and in values of hematological parameters such as RBC, MCV, MCHC, PLT, MPV, WBC, neutrophil, eosinophil, lymphocyte and monocyte counts. In group E, a decreasing trend of the values was observed in most cases, except for RBC, PLT, eosinophil, lymphocyte and monocyte counts. Similar results were obtained in the last two weeks of the experiment. Initially, exposure to DON has a stimulating effect, which is eliminated when adaptive mechanisms are triggered. The results of the study indicate that the intensity of biotransformation processes varies subjected to the body's energy resources.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

18

Numer

1

Opis fizyczny

p.223-231,ref.

Twórcy

autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in OLsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland
autor
  • BIOMIN Polska Sp. z o.o., Grochowska 16, 04-217 Warsaw, Poland
autor
  • Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland

Bibliografia

  • Accensi F, Pinton P, Callu P, Abella-Bourges N, Guelfi JF, Grosjean F, Oswald IP (2006) Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets. J Anim Sci 84: 1935-1942.
  • Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, Abrami R, Abiola FA, Oswald IP, Puel O (2013) New insights into mycotoxin mixtures: The toxicity of low doses of type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol 272: 191-198.
  • Alonso-Pozos I, Rosales-Torres AM, Avalos-Rodriguez A, Vergara-Onofre M, Rosado-Garcia A (2003) Mechanism of granulosa cell death during follicular atresia depends on follicular size. Theriogenology 60: 1071-1081.
  • Boermans HJ, Leung MCK (2007) Mycotoxins and the pet food industry: Toxicological evidence and risk assessment. Int J Food Microbiol 119: 95-102.
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  • Dänicke S, Brezina U (2013) Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: Consequences for diagnosis of exposure and intoxication and carry over. Food a Chem Toxicol 60: 58-75.
  • Dänicke S, Valenta H, Klobasa F, Doll S, Ganter M, Flachowsky G (2004). Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch Anim Nutr 58: 1-17.
  • De Angelis E, Monaci L, Visconti A (2014) Investigation on the stability of deoxynivalenol and DON-3 glucoside during gastro-duodenal in vitro digestion of a naturally contaminated bread model food. Food Control 43: 270-275.
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  • Gajęcka M, Stopa E, Tarasiuk M, Zielonka Ł, Gajęcki M (2013) The expression of type-1 and type-2 nitric oxide synthase in selected tissues of the gastrointestinal tract during mixed mycotoxicosis. Toxins 5: 2281-2292.
  • Grześk E, Grześk G, Koziński M, Stolarek W, Zieliński M, Kubica J (2011) Nitric oxide as a cause and a potential place therapeutic intervention in hypo responsiveness vascular in early sepsis. Folia Cardiologica 6: 36-43.
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  • Pinton P, Accensi F, Beauchamp E, Cossalter AM, Callu P, Grosjean F, Oswald IP (2008) Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. Toxicol Lett 177: 215-222.
  • Rotter BA, Thompson BK, Lessard M, Trenholm HL, Tryphonas H, (1994) Influence of low-level exposure to Fusarium mycotoxins on selected immunological and he-matological parameters in young swine. Fundam Appl Toxicol 23: 117-124.
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  • Tiemann U, Briissow KP, Kuchenmeister U, Jonas L, Kohlschein P, Pähland R, Dänicke S (2006) Influence of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected enzymatic and histological parameters of liver in gilts. Food a Chem Toxicol 44: 1228-1235.
  • Voälkel I, Schroäer-Merker E, Czerny CP (2011) The carry-over of mycotoxins in products of animal origin with special regard to its implications for the European Food Safety Legislation. Food Nutr Sci 2: 852-867.
  • Wang J, Ji HF, Hou CL, Wang SX, Zhang DY, Liu H, Shan DC, Wang YM (2014) Effects of Lactobacillus johnsonii XS4 supplementation on reproductive performance, gut environment, and blood biochemical and immunological index in lactating sows. Livest Sci 164: 96-101.
  • Waśkiewicz A, Beszterda M, Kostecki M, Zielonka Ł, Goliński P, Gajęcki M (2014) Deoxynivalenol in the gastrointestinal tract of immature gilts under per os toxin application. Toxins 6: 973-987.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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