Fluoxetine (SSRI) treatment of canine atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover trial

• Autorzy: Fujimura M. , Ishimaru H. , Nakatsuji Y.
• Języki publikacji: EN

Abstrakty

EN

This study investigated effects of a fluoxetine (selective serotonin reuptake inhibitors; SSRI, 1 mg/kg) on pruritus in canine atopic dermatitis (CAD). After 4-weeks of base-line observation, 8 dogs with CAD entered a 2-months randomized, double-blind, placebo-controlled, crossover trial comparing fluoxetine with placebo. Clinical efficacy was evaluated using a Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) and Pruritus Visual Analog Scale (PVAS). Six dogs completed the study [two out of eight dogs (both of them were Shiba Inu) dropped out from the study due to a depression]. CADESI-03 and PVAS between fluoxetine and placebo showed no significant difference statistically (P>0.05 and P>0.05 respectively). Fluoxetine showed no efficacy on pruritus in CAD. Further researches are needed for the treatment on pruritus of CAD.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2014
• Tom: 17
• Numer: 2
• Opis fizyczny: p.371-373,ref.

Twórcy

autor

Fujimura M.

• Fujimura Animal Allergy Hospital, 10-26 5-choume Aomatanihigashi, Mino, Osaka, 562-0022, Japan

autor

Ishimaru H.

• Fujimura Animal Allergy Hospital, 10-26 5-choume Aomatanihigashi, Mino, Osaka, 562-0022, Japan

autor

Nakatsuji Y.

• Fujimura Animal Allergy Hospital, 10-26 5-choume Aomatanihigashi, Mino, Osaka, 562-0022, Japan

Bibliografia

• Dunham SA, Fuller TE, McCall RB (2013) Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. Vet Dermatol 24: 48-53.
• Favrot C, Steffan J, Seewald W, Picco F (2010) A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 21: 23-31.
• Gonzales AJ, Humphrey WR, Messamore JE, Fleck TJ, Fici GJ, Shelly JA, Teel JF, Bammert GF, Marsella R, Sousa CA, Gonzales AJ, Fadok VA (2012) Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J AmVet Med Assoc 241: 194-207.
• Marsella R, Sousa CA, Gonzales AJ, Fadok VA (2012) Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc 241(2): 194-207.
• Rapoport JL, Ryland DH, Kriete M (1992) Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder. Arch Gen Psychiatry 49: 517-521.
• Roosterman D, Goerge T, Schneider SW, Bunnett NW, Steinhoff M (2006) Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 86: 1309-1379.
• Ständer S, Böckenholt B, Schürmeyer-Horst F, Weishaupt C, Heuft G, Luger TA, Schneider G (2009) Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study. Acta Derm Venereol 89: 45-51.
• Tey HL, Yosipovitch G (2011) Targeted treatment of pruritus: a look into the future. Br J Dermatol 165: 5-17.
• Wynchank D, Berk M (1998) Fluoxetine treatment of acral lick dermatitis in dogs: a placebo-controlled randomized double blind trial. Depress Anxiety 8: 21-23.

Identyfikatory

DOI

10.2478/pjvs-2014-005